Evidence map›Paper›PMID 40089547›Full record

ArticleNPJ microgravity2025

TRPML1 ion channel promotes HepaRG cell differentiation under simulated microgravity conditions.

Huancai Fan, Dongyuan Lü, Zheng Lu, Hangyu Li, Zijuan Qi, Shujin Sun, Dongshi Guan, Mian Long, Ming Gao, Sijin Liu

Abstract read
In one paragraph

Article in NPJ microgravity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Huancai FanState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, P.R. China.
Dongyuan LüUniversity of Chinese Academy of Sciences, Beijing, P.R. China.
Zheng LuUniversity of Chinese Academy of Sciences, Beijing, P.R. China.
Hangyu LiUniversity of Chinese Academy of Sciences, Beijing, P.R. China.
Zijuan QiState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, P.R. China.
Shujin SunUniversity of Chinese Academy of Sciences, Beijing, P.R. China.
Dongshi GuanUniversity of Chinese Academy of Sciences, Beijing, P.R. China.ORCID http://orcid.org/0000-0002-4433-3662
Mian LongUniversity of Chinese Academy of Sciences, Beijing, P.R. China.
Ming GaoState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, P.R. China. minggao@rcees.ac.cn.ORCID http://orcid.org/0000-0001-7892-8050
Sijin LiuState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, P.R. China.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22076212
6 · The paper itself

Abstract

Stem cell differentiation must be regulated by intricate and complex interactions between cells and their surrounding environment, ensuring normal organ and tissue morphology such as the liver

Identifiers

PMID40089547
PMCPMC11910645

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.