Evidence map›Paper›PMID 40089487›Full record

ArticleNature communications2025

Pd-catalyzed deuteration of aryl halides with deuterium oxide.

Yu Chen, Ruyi Yuan, Tongtong Zheng, Qingting Guo, Yingming Yao, Li Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Nickel-Catalyzed Boron-Mediated Saturative Trifunctionalization of Alkynes.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu Chen *Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China.
Ruyi Yuan *Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China.
Tongtong ZhengKey Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China.
Qingting GuoKey Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China.
Yingming YaoKey Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China. yaoym@suda.edu.cn.ORCID http://orcid.org/0000-0001-9841-3169
Li ZhangKey Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China. li.zhang@suda.edu.cn.ORCID http://orcid.org/0000-0002-3849-1664

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22401209
6 · The paper itself

Abstract

Late-stage deuteration of aryl halides with deuterium oxide is a highly desirable but challenging transformation, primarily due to the difficulty of activating inert carbon-halogen bonds and the umpolung of deuterium oxide in the presence of various functional groups. To achieve this transformation, efforts have been made to develop photo-chemical, electro-chemical, or mechano-chemical strategies. However, these approaches often require specialized setups or activated substrates. Despite the well-known functional group tolerance of palladium catalysis, which makes it valuable in late-stage functionalization, a palladium-catalyzed deuteration of aryl halides with deuterium oxide has remained elusive. Herein, a deuteration reaction of aryl bromides, chlorides, and triflates with deuterium oxide has been developed, through palladium catalysis. Chemical equivalent amount of D

Identifiers

PMID40089487
PMCPMC11910591

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.