ArticleOsteoarthritis and cartilage2025
Relationship between knee pain and depth-specific measures of proximal tibial subchondral bone density.
Article in Osteoarthritis and cartilage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Fusion of photon-counting CT and MRI improves assessment of the knee: a pilot study.Osteoarthritis imaging · 2026Article
- Structural osteoarthritis pathogenesis correlates with distinct pain and dysfunction profiles after ACL injury in rats.Lab animal · 2026Article
- Review
- Sex-Specific Associations of Radiographic Knee Osteoarthritis and Pain with Distal Tibia Bone Microarchitecture: the Study of Muscle, Mobility and Aging (SOMMA).Calcified tissue international · 2026Article
- Association between the cartilage volume and bone mineral density in symptomatic knee osteoarthritis and the mediating role of bone mineral content.BMC musculoskeletal disorders · 2026Article
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Authors and funding
8 authors.
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Abstract
backgroundAltered subchondral bone mineral density (BMD) may be a possible contributor to osteoarthritis (OA) pain. We evaluated the relation of compartment-specific proximal tibial BMD, at varying depths beneath the subchondral surface, to knee pain.
methodsMulticenter Osteoarthritis (MOST) study participants with knee CTs were included. A 3D imaging tool measuring BMD in relation to depth from the subchondral surface was used to assess proximal tibial subchondral BMD at depths of 0-2.5, 2.5-5.0, and 5-10 mm. Knee pain in the past 30 days was scored on a numeric rating scale (range 0-100), dichotomized at 40/100 to define the presence of at least moderate pain. We cross-sectionally evaluated the relation of subchondral BMD to the presence of knee pain using binomial regression with generalized estimating equations (to account for correlations between two knees per individual) for each compartment and depth in separate models and adjusted for age, sex, and body mass index (BMI).
resultsWe included 2082 participants (mean age: 61 years, 56.5% female, mean BMI: 29 kg/m
conclusionLower subchondral proximal tibial BMD measures were associated with the prevalence of moderate knee pain in individuals with or at risk for knee OA, without differences by depth or compartment. These findings suggest bone remodeling responses throughout subchondral bone contribute to the knee pain experience.
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