Evidence map›Paper›PMID 40088524›Full record

ReviewClinics (Sao Paulo, Brazil)2025

Phyllodes tumors of the breast: A comprehensive review of diagnosis, treatment, and follow-up.

Aline Rocha Donato, Rodrigo Goncalves, Jonathan Yugo Maesaka, Fernando Nalesso Aguiar, José Maria Soares, Carlos Alberto Ruiz, José Roberto Filassi, Edmund Chada Baracat

Registry-linked trialAbstract readReview
In one paragraph

Review in Clinics (Sao Paulo, Brazil), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07657169 (Efficacy and Safety of Molecular Subtype-Guided Postoperative Radiotherapy for Phyllodes Tumor of the Breast), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07657169 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy and Safety of Molecular Subtype-Guided Postoperative Radiotherapy for Phyllodes Tumor of the Breast: A Prospective, Open-Label, Randomized Controlled Trial

TypeinterventionalSponsorSun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityRan2026 to 2030Enrolled160ConditionsRadiotherapy, Adjuvant, Phyllodes Breast Tumor, Prognosis, Molecular TypingArmsPostoperative Radiotherapy (PORT)
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aline Rocha DonatoDiscipline of Gynecology, Department of Obstetrics and Gynecology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
Rodrigo GoncalvesDiscipline of Gynecology, Department of Obstetrics and Gynecology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil. Electronic address: rodgon82@yahoo.com.
Jonathan Yugo MaesakaDiscipline of Gynecology, Department of Obstetrics and Gynecology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil; Mastology Sector of the Gynecology Division, Instituto de Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil.
Fernando Nalesso AguiarBreast Pathology Sector of the Department of Pathological Anatomy, Instituto do Câncer do Estado de São Paulo, Universidade de São Paulo, São Paulo, SP, Brazil.
José Maria SoaresDiscipline of Gynecology, Department of Obstetrics and Gynecology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
Carlos Alberto RuizDiscipline of Gynecology, Department of Obstetrics and Gynecology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
José Roberto FilassiDiscipline of Gynecology, Department of Obstetrics and Gynecology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil; Mastology Sector of the Gynecology Division, Instituto de Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil.
Edmund Chada BaracatDiscipline of Gynecology, Department of Obstetrics and Gynecology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phyllodes Tumor (PT) of the breast is a rare type of fibroepithelial neoplasm, classified into benign, borderline, and malignant subtypes. These tumors are known to be locally aggressive and have an inherent potential for Local Recurrence (LR), even after adequate surgical treatment. Establishing strategies to reduce LR has become increasingly important, as 21 % to 36 % of patients experience disease recurrence despite achieving negative surgical margins. Although surgical resection of the lesion is the gold standard treatment for all subtypes of phyllodes tumors, the ideal extent of the surgical margin remains a topic of debate with no consensus in the literature. Adjuvant radiotherapy is suggested as a tool to improve local control of the disease and reduce the recurrence rate; however, published data on this approach are currently conflicting. In this review paper, the authors will provide a detailed analysis of the current evidence on the diagnosis, treatment, follow-up, outcomes, and future perspectives of phyllodes tumors.

Indexed as

Breast NeoplasmsPhyllodes TumorFemaleHumansNeoplasm Recurrence, LocalRadiotherapy, AdjuvantBreastBreast cancerBreast DiseasesBreast NeoplasmsFibrocystic breast diseasePhyllodes tumor

Identifiers

PMID40088524
PMCPMC11952851

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.