Evidence map›Paper›PMID 40088404›Full record

ArticleJournal of autism and developmental disorders2025

Sleep Disorders and Constipation in Autistic Children and Youth: Who Receives Standard of Care Drug Treatments?

Amber M Angell, Choo Phei Wee, Alexis Deavenport-Saman, Camille Parchment, Chen Bai, Olga Solomon, Larry Yin

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amber M AngellUniversity of Southern California, Los Angeles, CA, USA. aangell@usc.edu.ORCID http://orcid.org/0000-0002-1186-319X
Choo Phei WeeUniversity of Southern California, Los Angeles, CA, USA.
Alexis Deavenport-SamanUniversity of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8715-7531
Camille ParchmentUniversity of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-3310-731X
Chen BaiUniversity of Florida, Gainesville, FL, USA.
Olga SolomonUniversity of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-4505-3320
Larry YinUniversity of Southern California, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this retrospective cohort analysis was to investigate sex differences in receipt of standard of care sleep and constipation drug treatments among autistic children and youth with sleep disorder and constipation, respectively.

methodsWe used the data from the OneFlorida + Data Trust to analyze healthcare claims for 19,877 autistic patients with sleep disorder and 32,355 patients with constipation, ages 1 to 22. We used logistic regression to examine sex differences in receiving sleep and constipation treatments, and a multivariate logistic regression model to further assess sex differences in ever receiving sleep and constipation treatments, adjusting for age, race, ethnicity, and urbanicity.

resultsIn our multivariate analysis, autistic girls with sleep disorder were 1.27 times more likely than boys to receive sleep treatment (p < 0.0001). Although autistic girls with constipation appeared to be 1.10 times more likely than boys to receive treatment, it was not significantly different after adjusting for demographic and socio-economic characteristics (p = 0.372). Older children were 1.09 times more likely than younger children to receive sleep treatment (p < 0.0001) and 1.07 times more likely to receive constipation treatment (p < 0.0001).

conclusionWe did not find sex differences among autistic children for treatment of constipation, but autistic girls with sleep disorder were significantly more likely to have ever received treatment, which could indicate that girls experience more significant sleep disorders.

Indexed as

Autistic DisorderConstipationSleep Wake DisordersAdolescentChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesSex FactorsYoung AdultAutismConstipationCo-occurring conditionHealthcare claimsSleep disorder

Identifiers

PMID40088404
PMCPMC12589277

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.