Evidence map›Paper›PMID 40088393›Full record

ArticleJournal of materials science. Materials in medicine2025

Self-assembled injectable Icariin@ Ti

Jiahao Fu, Hao Chen, Yiqiao Zhao, Hongzhong Xi, Yixuan Huang, Chenglin Liu, Yaokun Wu, Wei Song, Xin Liu, Bin Du and 1 more

Abstract read
In one paragraph

Article in Journal of materials science. Materials in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiahao FuAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Hao ChenAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Yiqiao ZhaoSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu, China.
Hongzhong XiAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Yixuan HuangAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Chenglin LiuAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Yaokun WuAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Wei SongAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Xin LiuAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China. liuxinsurg@163.com.
Bin DuAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China. fsyy00608@njucm.edu.cn.
Guangquan SunAffiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China. sunguangquan1981@163.com.

Funding

Key Laboratory of Jiangsu Province for Chemical Pollution Control and Resources Reuse JSDW202252National Natural Science Foundation of China 82074471Science and Technology Development Programme Project of Jiangsu Provincial Administration of Traditional Chinese Medicine MS2023023
6 · The paper itself

Abstract

Local therapy involving injectable hydrogel systems loaded with doxorubicin (DOX) has garnered significant attention in the realm of osteosarcoma (OS) research. Nevertheless, it has been noted that the local delivery of high-dose DOX exerts a pronounced inhibitory impact on osteogenesis, which is detrimental to the restoration of functional capabilities after OS treatment. To address this challenge, we have designed a self-assembled injectable hydrogel system that integrates photodynamic and chemodynamic therapy, aiming to enhance efficacy while mitigating adverse effects on osteogenic differentiation. In this study, an injectable sodium alginate (SA) hydrogel was fabricated by encapsulating titanium carbide powder (Ti

Indexed as

Bone NeoplasmsDoxorubicinFlavonoidsHydrogelsOsteogenesisOsteosarcomaTitaniumAlginatesAnimalsCell DifferentiationCell Line, TumorDrug LiberationHumansInjectionsMesenchymal Stem CellsMiceAlginatesDoxorubicinFlavonoidsHydrogelsicariinTitanium

Identifiers

PMID40088393
PMCPMC11910421

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.