ArticleJournal of racial and ethnic health disparities2026
Blood Pressure and Heart Rate Response to Orthostasis in Somali Americans.
Article in Journal of racial and ethnic health disparities, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Not yet cited in PubMed.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Statins and CPAP in Adipose Tissue: A Randomized Clinical Trial in Obstructive Sleep Apnea
Evaluating the Prevalence and Implications of Obstructive Sleep Apnea Among Somali-Americans: A Translational Research Study
Disrupted Sleep in Somali Americans - Implications for Hypertension Risk
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Abstract
purposeCardiovascular health disparities are present in African Americans, but it remains unknown whether this phenomenon affects Somali Americans. Study of Somali Americans is warranted due to distinct genetic and cultural differences from African Americans of western African ancestry. Orthostatic hemodynamic responses have implications for cardiovascular risk, especially among African American females. We sought to examine race and sex differences in systolic (SAP) and diastolic (DAP) arterial pressure and heart rate (HR) responsiveness to standing. We hypothesized that SAP, DAP, and HR change from supine to standing position would be higher in Somali Americans.
methodsWe studied blood pressure and HR responsiveness in 139 (70 Somali, age 29 ± 10 years; 69 White, age 31 ± 9 years) participants. Supine SAP, DAP, and HR were measured after at least 5 min of supine rest, and again after 1 min of standing. SAP, DAP, and HR change was compared between groups.
resultsΔSAP and ΔDAP were similar between groups (race × sex: p > 0.05). However, HR responsiveness to orthostasis varied between race and sex comparisons (race × sex: p = 0.011). Somali females exhibited an augmented HR response to orthostasis compared to White females (Δ19 ± 13 vs. 11 ± 9 beats/min, p = 0.005) and Somali males (Δ19 ± 13 vs. 12 ± 9 beats/min, p = 0.020).
conclusionΔHR with standing is augmented in young female Somali Americans. These findings highlight an early potential impairment in hemodynamic regulation that may heighten future cardiovascular risk. Further work is warranted to identify the potential autonomic nervous system underpinnings that may contribute to potentiated orthostatic responses and cardiovascular risk in Somali American females. Trial Registration www. CLINICALTRIALS: gov ; unique identifier, NCT04124848; NCT05411029; NCT03308578.
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