ArticleMolecular neurobiology2025
DNA Methylation-Regulated ZDHHC13 Promotes the Progression of Parkinson's Disease.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Epigenetic regulators polyphenols in neurodegenerative diseases: a promising intervention strategy.Annals of medicine · 2026Review
- DNA Methylation as a Programmable Information Layer: From Molecular Marks to Disease State Engineering.International journal of molecular sciences · 2026Review
- DNA Methylation-Regulated ZDHHC24 Exacerbates the Risk of Intracranial Aneurysms.Brain and behavior · 2026Article
- Lifting the Veil on Neuroinflammation in Parkinson's Disease: A Bibliometric Analysis.Journal of inflammation research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies suggest that palmitoylation may influence proteins involved in neurotransmission and neurodegenerative changes, such as pathological α-synuclein. However, the role of palmitoylation in Parkinson's disease (PD) has not been systematically investigated. Additionally, findings on DNA methylation changes and PD-associated gene expression remain inconsistent. This study aims to explore the causal relationship and mechanisms between palmitoylation genes, DNA methylation, and PD using Mendelian Randomization (MR). This study employed two-sample MR analysis, summary-data-based Mendelian Randomization (SMR) analysis, and mediation analysis, utilizing PD GWAS data from the Finngen database, palmitoylation genes data from the eQTLGen database, and DNA methylation data from the GoDMC database. First, a two-sample MR analysis was used to evaluate the causal relationship between the palmitoylation genes and PD. Then, the SMR method was applied to validate the association between gene expression and PD. Finally, mediation analysis was conducted to explore the mediating effect of DNA methylation on the relationship between expression of palmitoylation genes and PD. Our study found a significant positive correlation between high expression of the ZDHHC13 gene and increased PD risk. Each 1 standard deviation increase in ZDHHC13 expression was associated with a 24.20% increase in PD risk. Further DNA methylation analysis identified two key methylation sites (cg00161556 and cg27379915), which indirectly influenced the occurrence of PD by regulating the expression of the ZDHHC13 gene. Mediation effect analysis revealed that the methylation sites cg00161556 and cg27379915 indirectly promoted the development of PD by regulating the expression of the ZDHHC13 gene, with the mediation effect of ZDHHC13 gene expression accounting for 63.72% and 57.61% of the total effect, respectively. Sensitivity analysis and SMR analysis supported our findings, indicating high statistical robustness. This study highlights the role of DNA methylation in regulating ZDHHC13 during PD progression, suggesting potential clinical applications such as ZDHHC13 as a biomarker or therapeutic target for early PD diagnosis and treatment.
Indexed as
Identifiers
40088380What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.