Evidence map›Paper›PMID 40088371›Full record

Trial reportInflammopharmacology2025

Ropivacaine effect on hemostasis and pain level in patients undergoing orthognathic surgery: a triple-blinded, randomized, clinical trial.

Majid Hosseini-Abrishami, Mozhgan Kazemian, Mohammad Javad Sedaghati, Mohammad Alipour, Melika Hoseinzadeh, Alireza Ghaffarian-Hosseini, Vahid Reza Askari

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Majid Hosseini-AbrishamiDepartment of Oral and Maxillofacial Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.
Mozhgan KazemianDepartment of Oral and Maxillofacial Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Javad SedaghatiDepartment of Oral and Maxillofacial Surgery, Guilan University of Medical Sciences, Rasht, Iran.
Mohammad AlipourDepartment of Anesthesiology, Mashhad University of Medical Sciences, Mashhad, Iran.
Melika HoseinzadehDental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID http://orcid.org/0000-0002-8463-956X
Alireza Ghaffarian-HosseiniStudent Research Committee, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran. GhaffarianHA4011@mums.ac.ir.
Vahid Reza AskariClinical Research Development Unit, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. askariv@mums.ac.ir.ORCID http://orcid.org/0000-0001-9268-6270

Funding

Mashhad University of Medical Sciences 971492
6 · The paper itself

Abstract

objectiveThis triple-blind, controlled clinical trial aimed to assess the effects of ropivacaine and lidocaine on hemodynamic factors, blood loss, opioid consumption, and postoperative pain in patients undergoing orthognathic surgery.

methodsThirty-two patients with Class III malocclusion scheduled for orthognathic surgery were included. The participants were randomly assigned to receive 0.5% ropivacaine or 2% lidocaine with 1:80,000 epinephrine for local anesthesia (n = 16). Hemodynamic parameters were recorded at various time intervals, which included heart rate (HR), systolic blood pressure, diastolic blood pressure, mean arterial pressure, oxygen saturation (SpO

resultsThe participants' mean age was 23.67 ± 4.56 years, and 75% were female. The groups were comparable in most measured outcomes. HR was significantly higher in the ropivacaine group at 30 and 60 min post-injection (P < 0.05). SpO

conclusionWithin the limitations of this study, both 0.5% ropivacaine and lidocaine with epinephrine demonstrated comparable effects on hemodynamic stability, intraoperative blood loss, postoperative pain levels, and opioid consumption in patients undergoing orthognathic surgery. These findings suggest that ropivacaine may serve as a safe and effective alternative to lidocaine for local anesthesia in orthognathic procedures.

Indexed as

Anesthetics, LocalHemostasisOrthognathic Surgical ProceduresPostoperative PainRopivacaineAdultAnalgesics, OpioidAnesthesia, LocalBlood Loss, SurgicalBlood PressureDouble-Blind MethodFemaleHeart RateHemodynamicsHumansLidocaineAnalgesics, OpioidAnesthetics, LocalLidocaineRopivacaineClass III malocclusionHemodynamicsLidocaineLocal anesthesiaOrthognathic surgeryRopivacaine

Identifiers

PMID40088371

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.