Evidence map›Paper›PMID 40088309›Full record

ArticleOdontology2025

Metabolic regulation and oxidative stress attenuation in LPS-stimulated macrophages by flavonoids.

Cristiane Duque, Natália Leal Vizoto, Gabriel Pereira Nunes, Geórgia Rondó Peres, Simone Nataly Busato Feiria, José Francisco Hofling, Luis Octavio Regasini

Abstract read
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In one paragraph

Article in Odontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cristiane DuqueFaculty of Dental Medicine, Universidade Católica Portuguesa, Viseu, Portugal. cristianeduque@yahoo.com.br.ORCID http://orcid.org/0000-0002-2575-279X
Natália Leal VizotoDepartment of Oral Diagnosis, Division of Oral Microbiology and Immunology, Faculty of Dentistry, University of Campinas, Piracicaba, SP, Brazil.
Gabriel Pereira NunesDepartment of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University, Araçatuba, SP, Brazil.
Geórgia Rondó PeresDepartment of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University, Araçatuba, SP, Brazil.
Simone Nataly Busato FeiriaDepartment of Oral Diagnosis, Division of Oral Microbiology and Immunology, Faculty of Dentistry, University of Campinas, Piracicaba, SP, Brazil.
José Francisco HoflingDepartment of Oral Diagnosis, Division of Oral Microbiology and Immunology, Faculty of Dentistry, University of Campinas, Piracicaba, SP, Brazil.
Luis Octavio RegasiniLaboratory of Antibiotics and Chemotherapeutics, Institute of Biosciences, Humanities and Exact Sciences (Ibilce), São Paulo State University (UNESP), São José do Rio Preto, Brazil.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001
6 · The paper itself

Abstract

Periodontal disease, prevalent in 20% to 50% of the population, is a chronic multifactorial inflammation caused by a dysbiotic oral biofilm, with gingivitis and periodontitis being the most common forms. Flavonoids, such as myricetin and catechin, have antioxidant and anti-inflammatory potential, reducing nitric oxide (NO) and reactive oxygen species (ROS) in lipopolysaccharide (LPS)-stimulated macrophages. This study compared the effects of different flavonoids on viability and oxidative response of LPS-stimulated macrophages. RAW 264.7 macrophages were cultured at a density of 1-5 × 10

Indexed as

FlavonoidsLipopolysaccharidesMacrophagesOxidative StressAnimalsAntioxidantsCatechinCell SurvivalKaempferolsMiceNitric OxideQuercetinRAW 264.7 CellsReactive Oxygen SpeciesAntioxidantsCatechinepigallocatechin gallateFlavonoidskaempferolKaempferolsLipopolysaccharidesmyricetinNitric OxideQuercetinReactive Oxygen SpeciesCell viabilityFlavonoidsMacrophagesNitric oxideOxygen reactive species

Identifiers

PMID40088309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.