ArticleArchives of dermatological research2025
Enrichment analysis of loci associated with psoriasis susceptibility identified in genome-wide association studies.
Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Genome-Wide Association Study of Psoriasis, Psoriatic Arthritis, Anti-TNF-α Response, and Polygenic Risk Score in a Russian Cohort.International journal of molecular sciences · 2026Article
- Targeting Non-coding RNAs in Neurodegeneration: Advances in Therapeutic RNA Modalities and Next-Gen Delivery Technologies.Current Alzheimer research · 2026Review
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Authors and funding
1 author.
Funding
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Abstract
Psoriasis is a chronic autoimmune skin disease that has been associated with many polymorphic genes based on genome-wide association studies (GWAS). To perform gene ontology and biological pathway analysis of genes associated with psoriasis and also to investigate the degree of commonality of psoriasis-associated loci with susceptibility loci of some other autoimmune diseases, a total of 319 psoriasis-associated polymorphic protein-coding genes were included in the analysis. The web-based Enrichr was used for performing present analysis. Cytokine-cytokine receptor interaction and JAK-STAT signaling were predicted by KEGG analysis. The top biological process and molecular function were positive regulation of cytokine production and cytokine receptor activity, respectively. The present findings revealed that the psoriasis-associated genes were significantly involved in the immune system and its functions, consistent with the autoimmune nature of the disease. The present study revealed that there were 10 genes shared between psoriasis and other 5 autoimmune diseases, interestingly, these genes were significantly enriched in the JAK-STAT pathway (adjusted p-value = 3.75e-5). There were several multifactorial diseases and complex traits that had a statistically significant commonality between their predisposing genes and psoriasis predisposing genes. The current findings suggest that the JAK-STAT pathway is likely involved in the pathogenesis of psoriasis, such as many other autoimmune diseases. Therefore, it is suggested that inhibitors that block the gene transcription of pro-inflammatory cytokines by blocking intracellular signaling pathways mediated by JAK-STAT may be a good model for the treatment of autoimmune diseases, including psoriasis.
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Registered trials
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