Evidence map›Paper›PMID 40088276›Full record

ArticleArchives of dermatological research2025

The causal effects between autoimmune thyroid disease and urticaria: evidence from a Mendelian randomization study.

Shunmin Mao, Ling Jiang, Chuhan Fu, Li Lei, Jing Chen, Qinghai Zeng

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shunmin MaoDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Ling JiangDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Chuhan FuDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Li LeiDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Jing ChenDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. 43700351@qq.com.
Qinghai ZengDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. zengqinghai@csu.edu.cn.

Funding

he Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University No. YX202007High level Health Talents in Hunan Province 20240304082Natural Science Foundation of Hunan Province No.2022JJ30880Young Elite Scientists Sponsorship Program by CACM CACM-2023-QNRC2-B30
6 · The paper itself

Abstract

Previous studies have suggested a comorbidity between autoimmune thyroid disease (AITD) and urticaria. However, the causal effects between AITD and urticaria remain unclear. This study employed genome-wide association study (GWAS) data to analyze the associations between AITD and urticaria through bidirectional Mendelian randomization (MR), meanwhile, examined the role of 731 immune traits as mediators between the two diseases through mediation analysis. The IVW results indicated that Graves' disease (GD) and Hashimoto's thyroiditis (HT) have a potential risk effect on urticaria, particularly increasing the risk of other and unspecified urticaria and idiopathic urticaria. Urticaria, mainly other and unspecified urticaria, dermatographic urticaria demonstrated a potential risk effect on HT. The mediation analysis revealed that GD likely increases the risk of other and unspecified urticaria by reducing CD4

Indexed as

Graves DiseaseHashimoto DiseaseUrticariaGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideAutoimmune thyroid diseaseGraves’ diseaseHashimoto’s thyroiditisImmune traitsMendelian randomization studyUrticaria

Identifiers

PMID40088276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.