Evidence map›Paper›PMID 40088168›Full record

ArticleMolecular pharmaceutics2025

Development and Characterization of the [

Chenkai Mao, Shicheng Li, Rencai Fan, Jiaqi Zhang, Xinying Fan, Zhen Shentu, Zhixiang Zhuang, Lei Gan

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. A Novel Anti-Cadherin-17 Monoclonal Antibody, CaAntibodies (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Cadherin 17 and digestive cancers: from diagnostic to therapeutic opportunities.Journal of experimental & clinical cancer research : CR · 2026
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chenkai MaoCenter for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province 215000, China.
Shicheng LiCenter for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province 215000, China.
Rencai FanCenter for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province 215000, China.
Jiaqi ZhangCenter for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province 215000, China.
Xinying FanDepartment of General Practice, Zhongshan Hospital of Fudan University, Shanghai 200032, China.
Zhen ShentuDepartment of Ultrasound, Shenzhen Children's Hospital, Shenzhen Pediatrics Institute of Shantou University Medical College, No. 7019, Yitian Road, Futian District, Shenzhen 518026, P.R. China.
Zhixiang ZhuangCenter for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province 215000, China.ORCID 0000-0003-3717-615X
Lei GanCenter for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province 215000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cadherin 17 (CDH17) is highly expressed in digestive system cancers, and the potential of nanobodies targeting CDH17 as imaging probes and delivery vehicles for radioactive β-particles warrants exploration for their theranostic potential in CDH17-overexpressing gastric cancer (GC). In this study, we screened an anti-CDH17 nanobody library and constructed two antibodies: anti-CDH17 VHH (recombinant nanobody fused with a polyhistidine tag) and anti-CDH17 VHH-ABD (recombinant nanobody fused with an albumin-binding domain). VHH targeting CDH17 and its derivative VHH-ABD were conjugated with DOTA and labeled with radionuclide

Indexed as

CadherinsLutetiumRadioimmunotherapyRadioisotopesSingle-Domain AntibodiesStomach NeoplasmsAnimalsCell Line, TumorFemaleHumansMiceMice, Inbred BALB CMice, NudeRadiopharmaceuticalsTissue DistributionXenograft Model Antitumor AssaysCadherinsCDH17 protein, humanLutetiumLutetium-177RadioisotopesRadiopharmaceuticalsSingle-Domain AntibodiesCDH17gastric cancerLutetium-177nanobodytumor radioimmunotherapy

Identifiers

PMID40088168
PMCPMC11980787

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.