Evidence map›Paper›PMID 40088075›Full record

ArticleMovement disorders clinical practice2025

Gastrointestinal Manifestations in Parkinson's Disease Using a Validated Arabic Version of Gastrointestinal Dysfunction Scale: A Multicenter Study.

Ali Soliman Shalash, Marwa Yassien Badr, Yara Salah, Shimaa Elgamal, Shaimaa Ahmed Elaidy, Eman Abdel-Mageed Elhamrawy, Hayam Abdel-Tawab, Eman Hamid, Ehab Ahmed El-Seidy, Noha Lotfy Dawood and 1 more

Abstract readMulticenter StudyValidation Study
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Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Ali Soliman ShalashDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0001-7012-5907
Marwa Yassien BadrDepartment of Neuropsychiatry, Faculty of Medicine, Tanta University, Tanta, Egypt.
Yara SalahDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Shimaa ElgamalNeuropsychiatry Department, Faculty of Medicine, Kafrelsheikh University, Kafr Elsheikh, Egypt.ORCID https://orcid.org/0000-0002-6210-5225
Shaimaa Ahmed ElaidyDepartment of Neurology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Eman Abdel-Mageed ElhamrawyNeurology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Hayam Abdel-TawabNeurology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Eman HamidDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ehab Ahmed El-SeidyDepartment of Neuropsychiatry, Faculty of Medicine, Tanta University, Tanta, Egypt.
Noha Lotfy DawoodDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Egyptian Parkinson Research Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastrointestinal symptoms (GIS) contribute to the morbidity of Parkinson's disease (PD), with limited specific assessment tools.

objectiveThis multicenter study aimed to translate and validate the Gastrointestinal Dysfunction Scale for PD (GIDS-PD) into an Arabic version and to investigate the characteristics of GIS and its correlates.

methodsA total of 162 patients with PD and 165 age- and sex-matched healthy controls were assessed using the GIDS-PD. Arabic version was assessed for test-retest reliability, construct validity, convert validity, and floor or ceiling effects. Patients were assessed also using the International Parkinson and Movement Disorders Society-Unified Parkinson's Disease Rating Scale, Non-motor Symptoms Scale, and Parkinson's Disease Questionnaire-39.

resultsThe Arabic version of the GIDS-PD exhibited proper convergent validity, inter- and intrarater consistency, and an acceptable ceiling effect. Compared to controls, patients exhibited significantly higher frequency of all GIDS-PD items: difficulty in passing stools (86.42%), experiencing hard stools (65%), sensation of incomplete evacuation (75.93%), abdominal pain (69.14%), abnormal increase in passing stools (50.62%), abdominal distention (85.19%), involuntary weight loss (48.77%), difficulty in swallowing (64.81%), excessive salivation (68.52%), heartburn (82.10%), and nausea (43.83%). GISs were correlated to disease duration, motor and nonmotor severity, motor complications, and poorer quality of life (QoL). Predictors of the GIDS-PD included disease stage, motor severity, nonmotor burden, age, and dopaminergic daily dosage.

conclusionThis multicenter study provided a validated Arabic version of GIDS-PD and demonstrated the high frequency of different GISs; their high correlation with motor severity, nonmotor burden, dopaminergic dosage, and age; and their negative impact on QoL, implying the importance of their assessment and management.

Indexed as

Gastrointestinal DiseasesParkinson DiseaseAgedFemaleHumansMaleMiddle AgedReproducibility of ResultsSeverity of Illness IndexSurveys and QuestionnairesconstipationgastrointestinalGastrointestinal Dysfunction Scale for Parkinson's Disease (GIDS‐PD)non‐motornonmotorParkinson's diseasevalidation

Identifiers

PMID40088075
PMCPMC12275008

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