Evidence map›Paper›PMID 40088037›Full record

ArticleHuman vaccines & immunotherapeutics2025

Nanovaccine loaded with seno-antigen target senescent cells to improve metabolic disorders of adipose tissue and cardiac dysfunction.

Kexin Zhang, Qiliang Yin, Yucen Ma, Mengyu Cao, Lingwei Li, Xinliang Jin, Jiyan Leng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Multicellular senescence programs in the aged heart.Journal of molecular and cellular cardiology plus · 2026
    Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kexin ZhangDepartment of Cadre Ward, The First Hospital of Jilin University, Changchun, China.
Qiliang YinDepartment of Cadre Ward, The First Hospital of Jilin University, Changchun, China.
Yucen MaDepartment of Cadre Ward, The First Hospital of Jilin University, Changchun, China.
Mengyu CaoDepartment of Cadre Ward, The First Hospital of Jilin University, Changchun, China.
Lingwei LiDepartment of Cadre Ward, The First Hospital of Jilin University, Changchun, China.
Xinliang JinDepartment of General Surgery, First Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China.
Jiyan LengDepartment of Cadre Ward, The First Hospital of Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The buildup of senescent cells exacerbates metabolic disorders in adipose tissue and contributes to aging-related cardiac dysfunction. Targeted clearance of senescent cells can markedly ameliorate these aging-related diseases. Here, we developed a novel nanovaccine (GK-NaV) loaded with seno-antigen that is self-assembled from the fusion of cationic protein (K36) and seno-antigen peptide (Gpnmb). The GK-NaV could be highly engulfed by bone marrow-derived dendritic cells (BMDCs) and efficiently present antigens on the cellular surface, thereby promoting DCs maturation and activation of CD8

Indexed as

Adipose TissueCellular SenescenceMetabolic DiseasesNanoparticlesVaccinesAnimalsCD8-Positive T-LymphocytesDendritic CellsDiet, High-FatMaleMiceMice, Inbred C57BLMyocytes, CardiacNanovaccinesNanovaccinesVaccinescardiac dysfunctionmetabolic disordersNanovaccinesenescent cellsseno-antigen

Identifiers

PMID40088037
PMCPMC11916409

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.