Evidence map›Paper›PMID 40087832›Full record

ArticleMolecular ecology2025

Assessing Microsatellite Variations in Plasmodium falciparum Following a Decade-Long Antimalaria Campaign in Kenya.

Elizabeth Hemming-Schroeder, Alfred Hubbard, Faith I Ebhodaghe, Tatiana Vorontsova, Daibin Zhong, Guofa Zhou, Eugenia Lo, Harrysone Atieli, Andrew Githeko, James W Kazura and 1 more

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Article in Molecular ecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Elizabeth Hemming-SchroederDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Alfred HubbardDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, North Carolina, USA.ORCID 0000-0003-4917-7272
Faith I EbhodagheDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA.ORCID 0000-0002-8439-622X
Tatiana VorontsovaDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Daibin ZhongProgram in Public Health, University of California, Irvine, California, USA.
Guofa ZhouProgram in Public Health, University of California, Irvine, California, USA.
Eugenia LoDepartment of Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, Pennsylvania, USA.
Harrysone AtieliCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Andrew GithekoCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
James W KazuraCenter for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA.
Guiyun YanProgram in Public Health, University of California, Irvine, California, USA.

Funding

Vector Biology of Invasive Anopheles stephensi in Rural to Urban Landscapes in EthiopiaU19AI129326 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Ming-Chieh Lee · 2017 to 2026
$19.9M
Ecology of African Highland MalariaR01AI050243 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI YAN, GUIYUN · 2001 to 2018
$8.8M
Research Training in Mosquito Genomics and Bioinformat*D43TW001505 · FIC · UNIVERSITY OF CALIFORNIA-IRVINE · PI Guiyun Yan · 2000 to 2026
$6.0M
Molecular epidemiology and serology of malaria under shifting agricultural practices in AfricaF32AI147460 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI HEMMING-SCHROEDER, ELIZABETH ANNE · 2019 to 2022
$171k
FIC NIH HHS D43 TW001505NIAID NIH HHS F32 AI147460NIAID NIH HHS R01 AI050243NIAID NIH HHS U19 AI129326
6 · The paper itself

Abstract

Anti-malaria interventions typically reduce the intensity of Plasmodium transmission, but the effects of reduced transmission on P. falciparum population biology remain unclear. Highly polymorphic microsatellite markers in P. falciparum were used to investigate genetic diversity, polyclonality and genetic structure among populations in areas of varying malaria transmission intensity across Kenya. We also assessed relationships between metrics derived from genetic data, transmission intensity estimates and bioclimatic variables. Despite an overall reduction in transmission intensity across Kenya from 2005 to 2014, we found that parasite populations maintained high genetic diversity and that genetic diversity correlated more closely with past transmission intensity estimates in the year 2000 as compared to contemporary estimates in 2014. In contrast, we found genetic structuring to be significant, consistent with our observation of shifting parasite migration patterns in western Kenya. Both genetic diversity and polyclonality increased with higher precipitation in the dry season, revealing the potential impacts of changing climate patterns on parasite population dynamics. Whereas fragmentation of P. falciparum populations increases opportunities for spatially targeted interventions in Kenya, the high genetic diversity of isolates in our study signals enhanced adaptability of parasites.

Indexed as

Genetics, PopulationGenetic VariationMalaria, FalciparumMicrosatellite RepeatsPlasmodium falciparumHumansKenyagenetic connectivitygenetic diversityPlasmodium falciparumpopulation structuretransmission intensity

Identifiers

PMID40087832
PMCPMC11936721

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.