ArticleJournal of intensive care2025
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024.
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Article in Journal of intensive care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
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Who cites it
32 citing papers in PubMed.
- Article
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- Prevalence and clinical implications of altered mental status in patients with infection presenting to the emergency department.Internal and emergency medicine · 2026Article
- Sepsis-Specific Risk Factors for Augmented Renal Clearance (ARC) and the Effect of Inflammation on Duration of ARC in Patients with Sepsis: A Single-Center Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Septic shock in the operating room immediately after surgery: a case requiring differentiation from drug-induced anaphylaxis.BMC anesthesiology · 2026Article
- Optimizing Timing and Dose of Starting Norepinephrine and Vasopressin in Septic Shock.Life (Basel, Switzerland) · 2026Review
- Use of Commercially Available Large Language Models to Generate Information Leaflets on Post-Intensive Care Syndrome: Clinical Utility Assessment.JMIR formative research · 2026Article
- Korean Society of Nephrology 2025 evidence-based clinical practice guideline for continuous kidney replacement therapy.Kidney research and clinical practice · 2026Article
- Korean Society of Nephrology 2025 Evidence-Based Clinical Practice Guideline for Continuous Kidney Replacement Therapy.Electrolyte & blood pressure : E & BP · 2026Review
- Association between initial norepinephrine dose and minute by minute mean arterial pressure.Critical care (London, England) · 2026Observational
- Optimizing infection management after cardiac arrest: addressing diagnostic uncertainty and therapeutic dilemmas-a narrative review.Journal of intensive care · 2026Review
- Targeting the Gut in Sepsis: Therapeutic Potential of Medical Gases.Biomolecules · 2026Review
- Early Methylene Blue for Mortality Reduction in High-Dose VasoPREssor-Dependent Septic Shock (EMPRESS): protocol for a multicenter randomized controlled trial.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Article
- Recognizing Coagulation Disorders in Sepsis in the Emergency Room: A Narrative Review.Journal of clinical medicine · 2026Review
- Performance of large language models and prompt engineering strategies for data extraction in systematic reviews.Frontiers in digital health · 2026Article
- Regional Adherence to Early Sepsis Management Bundle and Associated Mortality in Hong Kong Between 2009-2018.Open forum infectious diseases · 2026Article
- The Diagnostic and Prognostic Value of Procalcitonin and High-Sensitivity C-Reactive Protein in Early-Stage Burn Sepsis: A Retrospective Cohort Study.Journal of inflammation research · 2026Article
- Optimization of cefepime dosage regimens forGlobal health & medicine · 2025Article
- Optimal large language models to screen citations for systematic reviews.Research synthesis methods · 2025Article
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Authors and funding
158 authors.
Nobuaki Shime *Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. shime@koto.kpu-m.ac.jp.
Taka-Aki Nakada *Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Tomoaki YatabeEmergency Department, Nishichita General Hospital, Tokai, Japan.
Kazuma YamakawaDepartment of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Yoshitaka AokiDepartment of Anesthesiology and Intensive Care Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Shigeaki InoueDepartment of Emergency and Critical Care Medicine, Wakayama Medical University, Wakayama, Japan.
Toshiaki IbaDepartment of Emergency and Disaster Medicine, Juntendo University, Tokyo, Japan.
Hiroshi OguraDepartment of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Yusuke KawaiDepartment of Nursing, Fujita Health University Hospital, Toyoake, Japan.
Atsushi KawaguchiDivision of Pediatric Critical Care, Department of Pediatrics, School of Medicine, St. Marianna University, Kawasaki, Japan.
Tatsuya KawasakiDepartment of Pediatric Critical Care, Shizuoka Children's Hospital, Shizuoka, Japan.
Yutaka KondoDepartment of Emergency and Critical Care Medicine, Juntendo University, Urayasu Hospital, Urayasu, Japan.
Masaaki SakurayaDepartment of Emergency and Intensive Care Medicine, JA Hiroshima General Hospital, Hatsukaichi, Japan.
Shunsuke TaitoDivision of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University Hospital, Hiroshima, Japan.
Kent DoiDepartment of Emergency and Critical Care Medicine, The University of Tokyo, Tokyo, Japan.
Hideki HashimotoDepartment of Infectious Diseases, Hitachi Medical Education and Research Center University of Tsukuba Hospital, Hitachi, Japan.
Yoshitaka HaraDepartment of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Toyoake, Japan.
Tatsuma FukudaDepartment of Emergency and Critical Care Medicine, Toranomon Hospital, Tokyo, Japan.
Asako MatsushimaDepartment of Emergency and Critical Care, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Moritoki EgiDepartment of Anesthesia and Intensive Care, Kyoto University Hospital, Kyoto, Japan.
Shigeki KushimotoDivision of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takehiko OamiDepartment of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Kazuya KikutaniDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Yuki KotaniDepartment of Intensive Care Medicine Kameda Medical Center, Kamogawa, Japan.
Gen AikawaDepartment of Adult Health Nursing, College of Nursing, Ibaraki Christian University, Hitachi, Japan.
Makoto AokiDivision of Traumatology, National Defense Medical College Research Institute, Tokorozawa, Japan.
Masayuki AkatsukaDepartment of Intensive Care Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Hideki AsaiDepartment of Emergency and Critical Care Medicine, Nara Medical University, Nara, Japan.
Toshikazu AbeDepartment of Emergency and Critical Care Medicine, Tsukuba Memorial Hospital, Tsukuba, Japan.
Yu AmemiyaDepartment of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Ryo IshizawaDepartment of Critical Care and Emergency Medicine, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.
Tadashi IshiharaDepartment of Emergency and Critical Care Medicine, Juntendo University, Urayasu Hospital, Urayasu, Japan.
Tadayoshi IshimaruDepartment of Emergency Medicine, Chiba Kaihin Municipal Hospital, Chiba, Japan.
Yusuke ItosuDepartment of Anesthesiology, Hokkaido University Hospital, Sapporo, Japan.
Hiroyasu InoueDivision of Physical Therapy, Department of Rehabilitation, Showa University School of Nursing and Rehabilitation Sciences, Yokohama, Japan.
Hisashi ImahaseDivision of Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Haruki ImuraDepartment of Infectious Diseases, Rakuwakai Otowa Hospital, Kyoto, Japan.
Naoya IwasakiDepartment of Anesthesiology and Intensive Care Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Noritaka UshioDepartment of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Masatoshi UchidaDepartment of Emergency and Critical Care Medicine, Dokkyo Medical University, Tochigi, Japan.
Michiko UchiNational Hospital Organization Ibarakihigashi National Hospital, Naka-Gun, Japan.
Takeshi UmegakiDepartment of Anesthesiology, Kansai Medical University, Hirakata, Japan.
Yutaka UmemuraDivision of Trauma and Surgical Critical Care, Osaka General Medical Center, Osaka, Japan.
Akira EndoDepartment of Acute Critical Care Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan.
Marina OiDepartment of Emergency and Critical Care Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Akira OuchiDepartment of Adult Health Nursing, College of Nursing, Ibaraki Christian University, Hitachi, Japan.
Itsuki OsawaDepartment of Emergency and Critical Care Medicine, The University of Tokyo, Tokyo, Japan.
Yoshiyasu OshimaDepartment of Pharmacy, Kobe Tokushukai Hospital, Kobe, Japan.
Kohei OtaDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Takanori OhnoDepartment of Emergency and Crical Care Medicine, Shin-Yurigaoka General Hospital, Kawasaki, Japan.
Yohei OkadaDepartment of Preventive Services, Kyoto University, Kyoto, Japan.
Hiromu OkanoDepartment of Critical Care Medicine, St. Luke's International Hospital, Tokyo, Japan.
Yoshihito OgawaDivision of Trauma and Surgical Critical Care, Osaka General Medical Center, Osaka, Japan.
Masahiro KashiuraDepartment of Emergency and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Daisuke KasugaiDepartment of Emergency and Critical Care Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ken-Ichi KanoDepartment of Emergency Medicine, Fukui Prefectural Hospital, Fukui, Japan.
Ryo KamidaniDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Akira KawauchiDepartment of Critical Care and Emergency Medicine, Japanese Red Cross Maebashi Hospital, Maebashi, Japan.
Sadatoshi KawakamiDepartment of Anesthesiology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
Daisuke KawakamiDepartment of Intensive Care Medicine, Aso Iizuka Hospital, Iizuka, Japan.
Yusuke KawamuraDepartment of Rehabilitation, Showa General Hospital, Tokyo, Japan.
Kenji KandoriDepartment of Emergency and Critical Care Medicine, Japanese Red Cross Society Kyoto Daini Hospital , Kyoto, Japan.
Yuki KishiharaDepartment of Emergency and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Sho KimuraDepartment of Pediatric Critical Care Medicine, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan.
Kenji KuboDepartment of Emergency Medicine, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
Tomoki KuribaraDepartment of Acute and Critical Care Nursing, School of Nursing, Sapporo City University, Sapporo, Japan.
Hiroyuki KoamiDepartment of Emergency and Critical Care Medicine, Saga University, Saga, Japan.
Shigeru KobaDepartment of Critical Care Medicine, Nerima Hikarigaoka Hospital, Nerima, Japan.
Takehito SatoDepartment of Anesthesiology, Nagoya University Hospital, Nagoya, Japan.
Ren SatoDepartment of Nursing, Tokyo Medical University Hospital, Shinjuku, Japan.
Yusuke SawadaDepartment of Emergency Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
Haruka ShidaData Science, Medical Division, AstraZeneca K.K, Osaka, Japan.
Tadanaga ShimadaDepartment of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Motohiro ShimizuDepartment of Intensive Care Medicine, Ryokusen-Kai Yonemori Hospital, Kagoshima, Japan.
Kazushige ShimizuDepartment of Clinical Engineer, Tenri Hospital, Tenri, Japan.
Takuto ShiraishiDepartment of Cardiology, Aizawa Hospital, Matsumoto, Japan.
Toru ShinkaiThe Advanced Emergency and Critical Care Center, Mie University Hospital, Tsu, Japan.
Akihito TampoDepartment of Emergency Medicine, Asahiakwa Medical University, Asahikawa, Japan.
Gaku SugiuraDepartment of Critical Care and Emergency Medicine, Japanese Red Cross Maebashi Hospital, Maebashi, Japan.
Kensuke SugimotoDepartment of Anesthesiology and Intensive Care, Gunma University, Maebashi, Japan.
Hiroshi SugimotoDepartment of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan.
Tomohiro SuharaDepartment of Anesthesiology, Keio University School of Medicine, Shinjuku, Japan.
Motohiro SekinoDepartment of Anesthesiology and Intensive Care Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Kenji SonotaDepartment of Intensive Care Medicine, Miyagi Children's Hospital, Sendai, Japan.
Mahoko TaitoDepartment of Nursing, Hiroshima University Hospital, Hiroshima, Japan.
Nozomi TakahashiCentre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.
Jun TakeshitaDepartment of Anesthesiology, Osaka Women's and Children's Hospital, Izumi, Japan.
Chikashi TakedaDepartment of Anesthesia and Intensive Care, Kyoto University Hospital, Kyoto, Japan.
Junko TatsunoDepartment of Nursing, Kokura Memorial Hospital, Kitakyushu, Japan.
Aiko TanakaDepartment of Intensive Care, University of Fukui Hospital, Fukui, Japan.
Masanori TaniDivision of Critical Care Medicine, Saitama Children's Medical Center, Saitama, Japan.
Atsushi TanikawaDivision of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hao ChenDepartment of Pulmonary, Yokohama City University Hospital, Yokohama, Japan.
Takumi TsuchidaDepartment of Anesthesiology, Hokkaido University Hospital, Sapporo, Japan.
Yusuke TsutsumiDepartment of Emergency Medicine, National Hospital Organization Mito Medical Center, Ibaragi, Japan.
Takefumi TsunemitsuDepartment of Preventive Services, Kyoto University, Kyoto, Japan.
Ryo DeguchiDepartment of Traumatology and Critical Care Medicine, Osaka Metropolitan University Hospital, Osaka, Japan.
Kenichi TetsuharaDepartment of Critical Care Medicine, Fukuoka Children's Hospital, Fukuoka, Japan.
Takero TerayamaDepartment of Emergency Self-Defense, Forces Central Hospital, Tokyo, Japan.
Yuki TogamiDepartment of Acute Medicine & Critical Care Medical Center, National Hospital Organization Osaka National Hospital, Osaka, Japan.
Takaaki TotokiDepartment of Anesthesiology, Kyushu University Beppu Hospital, Beppu, Japan.
Yoshinori TomodaLaboratory of Clinical Pharmacokinetics, Research and Education Center for Clinical Pharmacy, Kitasato University School of Pharmacy, Tokyo, Japan.
Shunichiro NakaoDepartment of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Hiroki NagasawaDepartment of Acute Critical Care Medicine, Shizuoka Hospital Juntendo University, Shizuoka, Japan.
Yasuhisa NakataniDepartment of Nursing, Osaka University Hospital, Osaka, Japan.
Nobuto NakanishiDepartment of Disaster and Emergency Medicine, Kobe University, Kobe, Japan.
Norihiro NishiokaDepartment of Emergency and Crical Care Medicine, Shin-Yurigaoka General Hospital, Kawasaki, Japan.
Mitsuaki NishikimiDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Satoko NoguchiDepartment of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Suguru NonamiDepartment of Emergency and Critical Care Medicine, Kyoto Katsura Hospital, Kyoto, Japan.
Osamu NomuraMedical Education Development Center, Gifu University, Gifu, Japan.
Katsuhiko HashimotoDepartment of Emergency and Intensive Care Medicine, Fukushima Medical University, Fukushima, Japan.
Junji HatakeyamaDepartment of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Yasutaka HamaiDepartment of Preventive Services, Kyoto University, Kyoto, Japan.
Mayu HikoneDepartment of Emergency Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.
Ryo HisamuneDepartment of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Tomoya HiroseDepartment of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Ryota FukeDepartment of Internal Medicine, IMS Meirikai Sendai General Hospital, Sendai, Japan.
Ryo FujiiEmergency Department, Ageo Central General Hospital, Ageo, Japan.
Naoki FujieDepartment of Pharmacy, Osaka Psychiatric Medical Center, Hirakata, Japan.
Jun FujinagaEmergency and Critical Care Center, Kurashiki Central Hospital, Kurashiki, Japan.
Yoshihisa FujinamiDepartment of Emergency Medicine, Kakogawa Central City Hospital, Kakogawa, Japan.
Sho FujiwaraDepartment of Emergency Medicine, Tokyo Hikifune Hospital, Tokyo, Japan.
Hiraku FunakoshiDepartment of Emergency and Critical Care Medicine, Tokyobay Urayasu Ichikawa Medical Center, Urayasu, Japan.
Koichiro HommaDepartment of Emergency and Critical Care Medicine, Keio University School of Medicine, Shinjuku, Japan.
Yuto MakinoDepartment of Preventive Services, Kyoto University, Kyoto, Japan.
Hiroshi MatsuuraOsaka Prefectural Nakakawachi Emergency and Critical Care Center, Higashiosaka, Japan.
Ayaka MatsuokaDepartment of Emergency and Critical Care Medicine, Saga University, Saga, Japan.
Tadashi MatsuokaDepartment of Emergency and Critical Care Medicine, Keio University School of Medicine, Shinjuku, Japan.
Yosuke MatsumuraDepartment of Intensive Care, Chiba Emergency and Psychiatric Medical Center, Chiba, Japan.
Akito MizunoDepartment of Anesthesia and Intensive Care, Kyoto University Hospital, Kyoto, Japan.
Sohma MiyamotoDepartment of Emergency and Critical Care Medicine, St. Luke's International Hospital, Chuo-Ku, Japan.
Yukari MiyoshiDepartment of Emergency and Critical Care Medicine, Juntendo University, Urayasu Hospital, Urayasu, Japan.
Satoshi MurataDivision of Emergency Medicine, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
Teppei MurataDepartment of Cardiology Miyazaki Prefectural, Nobeoka Hospital, Nobeoka, Japan.
Hiromasa YakushijiDepartment of Emergency Medicine, Yakushiji Jikei Hospital, Soja, Japan.
Shunsuke YasuoDepartment of Radiology, Tenri Hospital, Tenri, Japan.
Kohei YamadaDepartment of Traumatology and Critical Care Medicine, National Defense Medical College Hospital, Saitama, Japan.
Hiroyuki YamadaDepartment of Primary Care and Emergency Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ryo YamamotoDepartment of Emergency and Critical Care Medicine, Keio University School of Medicine, Shinjuku, Japan.
Ryohei YamamotoCenter for Innovative Research for Communities and Clinical Excellence (CIRC2LE), Fukushima Medical University, Fukushima, Japan.
Tetsuya YumotoDepartment of Emergency, Critical Care and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Yuji YoshidaDepartment of Anesthesia and Intensive Care, Kyoto University Hospital, Kyoto, Japan.
Shodai YoshihiroDepartment of Pharmaceutical Services, Hiroshima University Hospital, Hiroshima, Japan.
Satoshi YoshimuraDepartment of Emergency Medicine, Rakuwakai Otowa Hospital, Kyoto, Japan.
Jumpei YoshimuraDepartment of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Hiroshi YonekuraDepartment of Anesthesiology and Pain Medicine, Fujita Health University Bantane Hospital, Nagoya, Japan.
Yuki WakabayashiDepartment of Nursing, Kobe City Medical Center General Hospital, Kobe, Japan.
Takeshi WadaDivision of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Shinichi WatanabeDepartment of Physical Therapy, Faculty of Rehabilitation Gifu, University of Health Science, Gifu, Japan.
Atsuhiro IjiriDepartment of Traumatology and Critical Care Medicine, National Defense Medical College Hospital, Saitama, Japan.
Kei UgataDepartment of Intensive Care Medicine, Matsue Red Cross Hospital, Matsue, Japan.
Shuji UdaDepartment of Anesthesia and Intensive Care, Kyoto University Hospital, Kyoto, Japan.
Ryuta OnoderaDepartment of Preventive Services, Kyoto University, Kyoto, Japan.
Masaki TakahashiDivision of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Satoshi NakajimaDepartment of Emergency Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Junta HondaDepartment of Emergency and Critical Care Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tsuguhiro MatsumotoDepartment of Anesthesia and Intensive Care, Kyoto University Hospital, Kyoto, Japan.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 2024 revised edition of the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock (J-SSCG 2024) is published by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine. This is the fourth revision since the first edition was published in 2012. The purpose of the guidelines is to assist healthcare providers in making appropriate decisions in the treatment of sepsis and septic shock, leading to improved patient outcomes. We aimed to create guidelines that are easy to understand and use for physicians who recognize sepsis and provide initial management, specialized physicians who take over the treatment, and multidisciplinary healthcare providers, including nurses, physical therapists, clinical engineers, and pharmacists. The J-SSCG 2024 covers the following nine areas: diagnosis of sepsis and source control, antimicrobial therapy, initial resuscitation, blood purification, disseminated intravascular coagulation, adjunctive therapy, post-intensive care syndrome, patient and family care, and pediatrics. In these areas, we extracted 78 important clinical issues. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) method was adopted for making recommendations, and the modified Delphi method was used to determine recommendations by voting from all committee members. As a result, 42 GRADE-based recommendations, 7 good practice statements, and 22 information-to-background questions were created as responses to clinical questions. We also described 12 future research questions.
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Evidence-based medicineGRADEInfectionIntensive careOrgan failureSystematic review
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