ArticleMobile DNA2025
Association of a 7.9 kb Endogenous Retrovirus Insertion in Intron 1 of CD36 with Obesity and Fat Measurements in Sheep.
Article in Mobile DNA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEndogenous retroviruses (ERVs) enhance genetic diversity in vertebrates, including sheep. This study investigates the role of Ov-ERV-R13-CD36 within CD36 gene and its association with phenotypic traits in sheep. Analyzing 58 sheep genomes revealed that ERVs constitute approximately 6.02% to 10.05% of the genomic content. We identified 31 retroviral insertion polymorphisms (RIPs) from 28 ERV groups. Among these, Ov-ERV-R13-CD36, which is specifically classified as a beta retrovirus, was selected for further analysis due to its location in CD36 gene, known for its role in fat metabolism, obesity (OB), body weight (BW), and body condition score (BCS). We assessed the association of Ov-ERV-R13-CD36 with OB and BCS across six sheep breeds, utilizing data from 1,355 individuals.
resultsGenomic analyses confirmed that Ov-ERV-R13-CD36 is located within CD36 gene on Chromosome 4, with polymorphisms across various sheep genomes. In a subset of 43 genomes, 22 contained the Ov-ERV-R13-CD36 insertion, while 21 exhibited wild-type variants. The studied animals showed variability in BCS and fat content associated with the Ov-ERV-R13-CD36 variant. Notably, Rahmani sheep exhibited a significantly higher BCS (4.62), categorized as obese, while Barki sheep displayed the lowest BCS (2.73), classified as thin to average. The association analysis indicated that sheep with the RIP
conclusionsFindings suggest that Ov-ERV-R13-CD36 within CD36 gene correlates with beneficial economic traits associated with OB and BCS, particularly in Rahmani and Romanov x Rahmani breeds. This indicates that Ov-ERV-R13-CD36 could be a valuable genetic marker for breeding programs aimed at enhancing traits like fat deposition and body condition in sheep.
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