ReviewJournal of nanobiotechnology2025
Nickel-based nanomaterials: a comprehensive analysis of risk assessment, toxicity mechanisms, and future strategies for health risk prevention.
Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Magnetically responsive electrospun fibers as programmable bioactive scaffolds: From formulation design to magnetically triggered therapy and regeneration.Bioactive materials · 2027Review
- Antibiotic-Free Strategies for Managing Antimicrobial-Resistant Infections.Pharmaceutics · 2026Review
- Recent Advances in Ferrite-Based Materials for Biomedical Applications: A Comprehensive Review.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Targeting Biofilms in Chronic Wounds: Emerging Strategies with Antimicrobial Nanocomposites.Journal of functional biomaterials · 2026Review
- Dose-Dependent Effects of Nickel on Skeletal Development: Physiological Necessity and the Threshold of Toxicity.International journal of molecular sciences · 2026Article
- Sustainable biosynthesis of NiO-carbon nanocomposites with enhanced charge dynamics for high-performance electrochemical pesticide detection in agricultural applications and photocatalytic remediation.Scientific reports · 2026Article
- Nickel Single-Atom Nanozyme for Multimodal Cancer Therapy.ACS applied materials & interfaces · 2026Article
- Magneto-X Effects in Magnetic Soft Materials and Their Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The application of metal nanomaterials in cancer diagnosis and treatment.Discover nano · 2026Review
- Overloaded mitochondrial stress drives reproductive damage in GC-1 mouse spermatogonia cells exposed to nickel nanoparticle.Cell biology and toxicology · 2026Article
- Mechanistic toxicity profiling of nicotine-rich e-liquids: mitochondrial and oxidative stress responses in ALI-exposed bronchial cells.Molecular and cellular biochemistry · 2026Article
- The Cross-Species Implantable ATP Battery Inspired by Photosynthesis for Application in Diseases.International journal of nanomedicine · 2026Review
- Nickel Bioaccumulation in Oral Biofilm, Gingival Tissue, and Saliva During Fixed Orthodontic Treatment: A 12-Month Prospective Cohort Study on Predictors and Salivary pH Correlation.Journal of clinical and experimental dentistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Nickel-based nanomaterials (NBNs) have seen a surge in usage across a variety of applications. However, the widespread use of NBNs has led to increased human exposure, raising questions about their associated health risks, both in the short and long term. Additionally, the spread of NBNs in the environment has attracted considerable attention, emerging as a vital focus for research and development. This review aims to provide an in-depth assessment of the current understanding of NBNs toxicity, the mechanisms underlying their toxicological effects, and the strategies for mitigating associated health risks. We begin by examining the physicochemical properties of NBNs, such as particle size, composition and surface functionalization, which are key determinants of their biological interactions and toxicity. Then, through an extensive analysis of in vitro and in vivo studies, we highlight the adverse effects of NBNs exposure, including the generation of reactive oxygen species (ROS), oxidative stress, inflammation, cytotoxicity, genotoxicity, and immunotoxicity. To address the potential health risks associated with NBNs, we propose future strategies for risk prevention, including the development of safer nanomaterial designs, implementation of stringent regulatory guidelines, and advancement of novel toxicity testing approaches.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.