ArticleBMC veterinary research2025
Physio-metabolic response, immune function, epigenetic markers, and reproductive performance of rabbits under environmental stress: the mitigating role of boswellia essential oil nanoemulsion.
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Unraveling the cytoprotective mechanism of polysaccharides in heat-stressed rabbits: antioxidant, anti-inflammatory, physiological status, and molecular docking assessment.Veterinary research communications · 2026Article
- Dietary yeast-derived nucleotides enhance reproductive efficiency, blood metabolic profile, antioxidant status, and immune function in rabbit does.Veterinary research communications · 2026Article
- Potential symbiotic effects of Artemia franciscana extract on post-metabolic response, antioxidant defense, reproductive performance, and tissue integrity in rabbit does.Veterinary research communications · 2026Article
- Moringa supplementation effects on productive performance of heat stressed growing calves.Tropical animal health and production · 2026Article
- Functional role of Dictyota dichotoma extract in mitigating heat stress adverse effects and enhancing physiological resilience in growing rabbits.Tropical animal health and production · 2025Article
- Therapeutic potential of Boswellia serrata in arthritis management: mechanistic insights into COX-2, 5-LOX, and NFĸB modulation.Inflammopharmacology · 2025Review
- Improving heat resilience in fattening rabbits: nutritional strategies for mitigation via regulating blood physiology, inflammation and antioxidant pathways.Frontiers in veterinary science · 2025Article
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7 authors.
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Abstract
Global warming poses a significant threat to reproductive health of rabbits. Sustainable nutritional strategies are crucial for ensuring rabbit production and maintaining food security under these challenging conditions. This study sought to assess the protective benefits of dietary boswellia essential oil nano-emulsion (BEON) against oxidative stress, immune dysregulation, ferroptosis, and organ damage in female rabbits exposed to severe thermal stress. A total of 120 female rabbits were divided into four groups of 30 rabbits each. The rabbits were fed a basal diet supplemented with 0 (BEON0), 0.25 (BEON0.25), 0.5 (BEON0.5), and 1.0 (BEON1.0) mL of BEON per kilogram of diet. Results demonstrated that the BEON1.0 group exhibited significantly higher levels of IgG, superoxide dismutase (SOD), and glutathione peroxidase (GPx), while the BEON0.25 group showed elevated levels of IgM, catalase, and total antioxidant capacity (TAC) (P < 0.05). All BEON treatments significantly reduced malondialdehyde (MDA) levels (P < 0.01). Serum levels of progesterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were significantly elevated in the BEON0.5 and BEON1.0 groups compared to the control group (P < 0.01). A significant decrease in adipokine levels was observed in all BEON-supplemented groups compared to the control group (P < 0.05). All BEON groups demonstrated a modulation of ferroptosis pathways, characterized by decreased heat shock protein 70 (HSP70) expression and upregulated expression of glutathione peroxidase 4 (GPX4) and cystine transporter solute carrier 7A11 (SLC7A11) in ovarian tissues (P < 0.01). Furthermore, DNA methyltransferase 1 (DNMT1) expression increased in a dose-dependent manner with increasing BEON supplementation. Histological analysis revealed an improvement in the architecture of the liver, uterine horns, and ovarian tissues in rabbits fed BEON. Integrating BEON at doses of 0.5-1.0 mL/kg diet significantly improved reproductive performance in stressed female rabbits. PCA and correlation analyses demonstrated a positive correlation between BEON supplementation and immune function, reproductive hormone levels, and antioxidant status, while a negative correlation was observed with MDA and adipokine concentrations in rabbit serum. In conclusion, BEON supplementation demonstrates promise as a sustainable nutritional strategy for the rabbit industry, particularly in mitigating the challenges posed by global warming.
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