Evidence map›Paper›PMID 40087715›Full record

ArticleBMC musculoskeletal disorders2025

Natural course of postoperative C-reactive protein and erythrocyte sedimentation rate in unilateral and simultaneous bilateral total knee arthroplasty.

Mustafa Alper Incesoy, Cemil Burak Demirkiran, Hakan Batuhan Kaya, Muhammed Ali Geckalan, Aysegul Yabaci Tak, Nurzat Elmali, Fatih Yildiz, Gokcer Uzer

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In one paragraph

Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07688642 (Boosting Venous Return After Knee Replacement), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07688642 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Boosting Venous Return After Knee Replacement: Effects of a Novel Circulatory Exercise on Early Postoperative Inflammation - A Randomized Controlled Trial

TypeinterventionalSponsorAssiut UniversityRan2026 to 2027Enrolled68ConditionsTotal Knee Replacement, Knee Osteoarthritis, Postoperative Edema, Postoperative InflammationArmsstandard postoperative TKR rehabilitation, Standard Rehabilitation Plus Circulatory Exercise
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mustafa Alper IncesoyDepartment of Orthopedics, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey. alperincesoy@gmail.com.
Cemil Burak DemirkiranDepartment of Orthopedics, Kilis Prof. Dr. Alaeddin Yavaşca State Hospital, Kilis, Turkey.
Hakan Batuhan KayaDepartment of Orthopedics, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Muhammed Ali GeckalanDepartment of Orthopedics, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Aysegul Yabaci TakDepartment of Biostatistics and Medical Informatics, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Nurzat ElmaliDepartment of Orthopedics, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Fatih YildizDepartment of Orthopedics, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Gokcer UzerDepartment of Orthopedics, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundC-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are valuable markers for detecting periprosthetic joint infection (PJI) post-total knee arthroplasty (TKA). However, their prolonged elevation after TKA diminishes diagnostic reliability. This study investigates CRP and ESR trends in unilateral (U-TKA) and simultaneous bilateral TKA (SB-TKA) patients, comparing their patterns.

methodsBetween 2017 and 2023, preoperative and postoperative (weeks 2, 4, 6) CRP and ESR levels were assessed in U-TKA (32 patients) and SB-TKA (29 patients) groups for gonarthrosis.

resultsMedian preoperative CRP levels were 1.13 mg/dL (U-TKA) and 0.2 mg/dL (SB-TKA), with corresponding ESR levels of 13.50 mm/h and 10 mm/h. While CRP and ESR increased more in SB-TKA, differences were statistically insignificant (p > 0.05). Both groups showed significant differences in CRP and ESR values at all time points (p < 0.05). U-TKA patients reached CRP < 5 mg/dL and ESR < 30 mm/h by the 6th postoperative week. SB-TKA patients did not exhibit significantly higher CRP and ESR levels at various intervals compared to U-TKA patients (p > 0.05).

conclusionThis study delineates postoperative CRP and ESR trends in U-TKA and SB-TKA for osteoarthritis. CRP values decreased below 5 mg/dL, and ESR values below 30 mm/h within 6 weeks in both groups. Statistically significant differences in CRP and ESR values were observed at all time points. No significant differences were found in CRP and ESR trends between both groups. These findings aid physicians in interpreting laboratory reports for PJI determination. LEVEL OF EVIDENCE: III.

Indexed as

Arthroplasty, Replacement, KneeBlood SedimentationC-Reactive ProteinProsthesis-Related InfectionsAgedBiomarkersFemaleHumansMaleMiddle AgedOsteoarthritis, KneePostoperative PeriodRetrospective StudiesBiomarkersC-Reactive ProteinC-Reactive ProteinErythrocyte Sedimentation RateKneePeriprosthetic Joint infectionTotal knee arthroplasty

Identifiers

PMID40087715
PMCPMC11907866

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