Evidence map›Paper›PMID 40087701›Full record

Trial reportBMC musculoskeletal disorders2025

Analgesic effect of ropivacaine combined with methylene blue in fascia Iliaca block for patients undergoing hip arthroplasty.

Yang Zhang, Shun Yang, Zi-Ru Lu, Feng Zhou, Mei-Yu Liu

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06284941 (A Study of Ropivacaine Complex Methylene Blue Fascia Iliaca Compartment Block on Analgesia in Patients Undergoing Hip Arthroplasty), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06284941 nacompletednot on this map

A Study of Ropivacaine Complex Methylene Blue Fascia Iliaca Compartment Block on Analgesia in Patients Undergoing Hip Arthroplasty

TypeinterventionalSponsorWang wanxiaRan2023 to 2024Enrolled90ConditionsFemoral Neck DiseaseArmsRopivacaine combined with methylene blue for iliac fascia block
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yang Zhang *Department of Anesthesiology, Taizhou Jiangyan Hospital of TCM, Taizhou, 225500, China.
Shun Yang *Department of Anesthesiology, Taizhou Jiangyan Hospital of TCM, Taizhou, 225500, China.
Zi-Ru Lu *Department of Orthopedic, Taizhou Jiangyan Hospital of TCM, Taizhou, 225500, China.
Feng ZhouDepartment of Orthopedic, Taizhou Jiangyan Hospital of TCM, Taizhou, 225500, China.
Mei-Yu LiuDepartment of Anesthesiology, Jiangdu People's Hospital Affiliated to Yangzhou University, No. 100, Jiangzhou Road, Jiangdu District, Yangzhou, 225200, China. myliu@yzu.edu.cn.

Funding

Science and Technology Support Program (Social Development) of Taizhou City, Jiangsu Province SSF20230101
6 · The paper itself

Abstract

backgroundThe duration of a single fascia iliaca compartment block (FICB) with ropivacaine is limited. This study investigated whether methylene blue as an adjuvant anesthetic in FICB can enhance the postoperative analgesic effect following total hip arthroplasty (THA).

methodsPatients who planned to undergo THA were recruited for this randomized clinical trial from June 2023 to February 2024. Ninety elderly patients undergoing THA were randomly divided into two groups that received ultrasound-guided FICB with either ropivacaine and methylene blue (MB + R group, n = 45) or ropivacaine only (R group, n = 45) before induction of general anesthesia. The primary outcomes were postoperative Visual Analog Scale (VAS) scores. Secondary outcomes included inflammatory factor levels, heart rate (HR), mean arterial pressure (MAP), postoperative analgesic use, postoperative activity, and adverse events.

resultsThe MB + R group had significantly lower VAS scores at both rest and with activity at 24 and 48 h postoperatively than the R group (P < 0.001). Additionally, the hypersensitive C-reactive protein, procalcitonin, and neutrophil-to-lymphocyte ratio values were significantly lower in the MB + R group than in the R group on the first and second days after surgery (P < 0.05). The number of patients requiring supplemental analgesia postoperatively was significantly lower in the MB + R group (P = 0.020). Additionally, the MB + R group had a significantly longer walking distance on the first time out of bed and a higher number of out-of-bed activities within 48 h postoperatively (P < 0.001).

conclusionCompared to ropivacaine alone, the combination of ropivacaine and methylene blue in FICB provided better analgesic effects over a longer duration. Additionally, the addition of methylene blue reduced the postoperative production of inflammatory markers and promoted patients' functional recovery.

trial registrationClinicalTrials.gov, Registration number: NCT06284941, Retrospectively registered, Date of registration: February 04, 2024.

Indexed as

Anesthetics, LocalArthroplasty, Replacement, HipMethylene BlueNerve BlockPostoperative PainRopivacaineAgedDrug Therapy, CombinationFasciaFemaleHumansMaleMiddle AgedPain MeasurementTreatment OutcomeUltrasonography, InterventionalAnesthetics, LocalMethylene BlueRopivacaineAnalgesiaFascia Iliaca compartment blockMethylene blueRopivacaineTotal hip arthroplasty

Identifiers

PMID40087701
PMCPMC11907882

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.