Evidence map›Paper›PMID 40087696›Full record

ArticleNutrition journal2025

Low-calorie diets and remission of type 2 diabetes in Chinese: phenotypic changes and individual variability.

Zhenxiu Liu, Nannan Feng, Sujing Wang, Yang Liu, Jie Wang, Yue Tan, Ying Dong, Zhewei Sun, Xihao Du, Yaqing Xu and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05472272 (Effect of Low-Calorie Diets on Remission of Type 2 Diabetes), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05472272 nacompletednot on this map

Effect of Low-Calorie Diets on Remission of Type 2 Diabetes: A Feasibility Study

TypeinterventionalSponsorShanghai Municipal Hospital of Traditional Chinese MedicineRan2022 to 2024Enrolled42ConditionsType 2 Diabetes Mellitus, Obesity, OverweightArmsFormula diet, Food-based diet
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhenxiu Liu *Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200025, China.
Nannan Feng *Department of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 415 East No. 1 Building 227 South Chongqing Rd, Shanghai, China.
Sujing WangDepartment of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 415 East No. 1 Building 227 South Chongqing Rd, Shanghai, China.
Yang LiuDepartment of Clinical Nutrition, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jie WangDepartment of Chinese Medicine & Integrative Medicine, Shanghai Geriatric Medical Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Yue TanShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200025, China.
Ying DongDepartment of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 415 East No. 1 Building 227 South Chongqing Rd, Shanghai, China.
Zhewei SunDepartment of Health and Behavioral Studies, Teachers College, Columbia University, New York, USA.
Xihao DuDepartment of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 415 East No. 1 Building 227 South Chongqing Rd, Shanghai, China.
Yaqing XuDepartment of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 415 East No. 1 Building 227 South Chongqing Rd, Shanghai, China.
Feng TaoShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200025, China.
Victor W ZhongDepartment of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 415 East No. 1 Building 227 South Chongqing Rd, Shanghai, China. wenze.zhong@shsmu.edu.cn.

Funding

National Key Research and Development Program of China 2023YFC2506700National Natural Science Foundation of China 82373551, 82304117Science and Technology Commission of Shanghai Municipality 23Y11921500Shanghai Medical Innovation & Development Foundation WLJH2021ZY-GZS005, WL-XJRY-2021001K, WL-LCZD-2022001KShanghai Municipal Health Commission B01A3, GWVI-11.1-20
6 · The paper itself

Abstract

backgroundChinese have distinct phenotypes of type 2 diabetes (T2D) and obesity compared with people of other ethnicities, but using low-calorie diets to achieve T2D remission has never been conducted in Chinese. This study aimed to assess if T2D remission can be achieved using low-calorie formula diet (LCFD) and low-calorie real food-based diet (LCRFD) in Chinese similarly to other populations and to identify determinants of individual variability in T2D remission.

methodsThis 6-month intervention consisted of a 3-month isocaloric intensive weight loss phase (815-835 kcal/d) and a 3-month weight maintenance phase. Enrolled participants with T2D had BMI of 24-45 kg/m

resultsAt 6 months, 29.3% of participants had ≥ 12 kg weight loss, 39.0% lost ≥ 10% weight, and 56.1% achieved T2D remission. MRI-derived liver and pancreatic fat decreased significantly. Significant improvement was also seen in insulin sensitivity, continuous glucose monitoring-derived metrics, and various other cardiometabolic risk factors but not arginine-induced insulin secretory response. There was no difference in all outcomes between LCFD and LCRFD. Compared with responders for T2D remission, nonresponders were more likely to be women, and had more fat mass, longer diabetes duration, poorer glycemic control, and lower beta-cell function.

conclusionsT2D remission rate and weight loss amount following low-calorie diet intervention in Chinese people were comparable to those reported from other populations, although individual variability existed. LCFD and LCRFD were similarly effective.

trial registrationThe trial was registered with ClinicalTrials.gov: NCT05472272.

Indexed as

Caloric RestrictionDiabetes Mellitus, Type 2AdultAgedBlood GlucoseChinaEast Asian PeopleFemaleGlycated HemoglobinHumansInsulin ResistanceMaleMiddle AgedPhenotypeRemission InductionWeight LossBlood GlucoseGlycated HemoglobinLow-calorie dietRemissionType 2 diabetesVariabilityWeight loss

Identifiers

PMID40087696
PMCPMC11908006

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.