Evidence map›Paper›PMID 40087695›Full record

ArticleBMC complementary medicine and therapies2025

Chemical composition, antioxidant, antimicrobial, and anticancer activities of Mahonia napaulensis DC. bark from Nepal.

Rajib Kumar Shrestha, Satyabrata Nayak, Prabal Singh Maharjan, Bivek Pokharel, Gagan Deep Jhingan, Rana Pratap Singh, Neel Sarovar Bhavesh, Bhupal Govinda Shrestha

Abstract read
In one paragraph

Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rajib Kumar ShresthaDepartment of Chemical Science and Engineering, Kathmandu University, Dhulikhel, Nepal.
Satyabrata NayakCancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Prabal Singh MaharjanDepartment of Biotechnology, Kathmandu University, Dhulikhel, Nepal.
Bivek PokharelDepartment of Biotechnology, Kathmandu University, Dhulikhel, Nepal.
Gagan Deep JhinganVProteomics, Valerian Chem Pvt. Ltd., A69, Ground & First Floor, Sector-2, Gautam Buddha Nagar, Noida, Uttar Pradesh, 201301, India.
Rana Pratap SinghCancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Neel Sarovar BhaveshTranscription Regulation Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, 110067, India.
Bhupal Govinda ShresthaDepartment of Biotechnology, Kathmandu University, Dhulikhel, Nepal. bgs@ku.edu.np.

Funding

University Grants Commission (UGC), Nepal CRG-73/74-S&T-03
6 · The paper itself

Abstract

backgroundCancer is one of the major health problems worldwide and medicinal plants constitute a common alternative for cancer treatment having no or fewer side effects. This study aimed to assess total phenolic (TPC) and flavonoid (TFC) contents, antioxidant, biological activities (especially antibacterial, antifungal, and anticancer), and chemical composition of methanol extract of M. napaulensis DC. bark (MNBM). This is the first study evaluating its anticancer activity and chemical composition by LC-MS/MS analysis.

methodsTPC, TFC, antioxidant, antimicrobial, and anticancer activities were determined by Folin-Ciocalteu, AlCl

resultsThe preliminary phytochemical screening revealed the presence of various phytochemicals viz. alkaloids, steroids, glycosides, polyphenols, tannins, flavonoids, coumarins, terpenoids, and quinone. MNBM showed 38.00 ± 1.50 mg GAE g

Indexed as

Anti-Infective AgentsAntineoplastic AgentsAntineoplastic Agents, PhytogenicAntioxidantsPlant ExtractsCell Line, TumorFlavonoidsHumansMicrobial Sensitivity TestsNepalPhenolsPhytochemicalsPlant BarkAnti-Infective AgentsAntineoplastic AgentsAntineoplastic Agents, PhytogenicAntioxidantsFlavonoidsPhenolsPhytochemicalsPlant ExtractsAnticancerAntimicrobialAntioxidantDPPHLC–MS/MSMahonia napaulensis DC.MTTPhytochemicalsResazurin

Identifiers

PMID40087695
PMCPMC11907818

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.