ArticleBMC musculoskeletal disorders2025
A magnesium calcium phosphate-based cement as a bone adhesive: characterization and biomechanical evaluation.
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUsually, comminuted fractures contain fragments that are too small for fixation with Kirschner (K)-wires or screws. For those bony or osteochondral fragments, a bone adhesive would be desirable to, for example, enable easy anatomic reduction, avoid discarding of the fragments, and enable temporary fixation to visualize reduction before definitive osteosynthesis is performed. Most of the currently available bone adhesives have shortcomings, such as cytotoxicity, lack of resorbability, and inadequate mechanical properties. Thus, there is room for improved bone adhesives. The present work involves synthesis, characterization, and biomechanical evaluation of three variants of a novel magnesium calcium phostphate-based cement that may be used as a bone adhesive.
methodsThree novel experimental formulations of a magnesium calcium phosphate-based cement and a commercially-available cyanoacrylate bone adhesive (Glubran
resultsAmong the experimental cement formulations, HT-MPC had the highest compressive strength (26.8 ± 9.5 MPa), MPCa_22.5 had the highest cyclic increasing load-to-failure (162 ± 40 N) and the highest load-to-failure (295 ± 84 N), while the highest calculated shear strength was obtained with both MPC_25 and MPCa_22.5 (0.27 ± 0.12 and 0.26 ± 0.06 MPa, respectively), and the highest torque-to-failure was obtained with both MPCa_22.5 and HT-MPC (2.2 ± 0.8 and 2.1 ± 1.2 Nm, respectively). The calculated shear strength for the experimental cement formulations (0.13-0.38 MPa) is above the minimum that has been suggested to be required for a bone adhesive to be used in clinical practice (0.2 MPa). Relative to the experimental cement formulations, the compressive strength of Glubran
conclusionsEach of the synthesized novel magnesium calcium phosphate-based cement formulations has adequate compressive strength, shear strength and resistance to fatigue failure. Thus, each merits further study for use in intraoperative fixation of small bone fragments.
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