Evidence map›Paper›PMID 40087677›Full record

ArticleBMC cancer2025

Pilot study of ultrasound-guided microwave ablation for inactivating excess remnant thyroid after surgery in patients with differentiated thyroid cancer.

Yihao Chen, Rongwei Hu, Chunchun Jin, Leidan Huang, Yiqin Lin, Bingzi Zou, Xiaorui Liu, Zhilin Li, Zhengyi Li, Weizong Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yihao Chen *Department of Ultrasound, Huizhou Central People's Hospital, Huizhou Guangdong, 516001, Guangdong, China.
Rongwei Hu *Department of Internal Medicine, Huizhou Central People's Hospital, Huizhou, 516001, Guangdong, China.
Chunchun Jin *Department of Ultrasound, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen Guangdong, 518035, Guangdong, China.
Leidan HuangDepartment of Ultrasound, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen Guangdong, 518035, Guangdong, China.
Yiqin LinDepartment of Ultrasound, Huizhou Central People's Hospital, Huizhou Guangdong, 516001, Guangdong, China.
Bingzi ZouDepartment of Ultrasound, Huizhou Central People's Hospital, Huizhou Guangdong, 516001, Guangdong, China.
Xiaorui LiuDepartment of Ultrasound, Huizhou Central People's Hospital, Huizhou Guangdong, 516001, Guangdong, China.
Zhilin LiDepartment of Ultrasound, Huizhou Central People's Hospital, Huizhou Guangdong, 516001, Guangdong, China.
Zhengyi LiDepartment of Ultrasound, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen Guangdong, 518035, Guangdong, China.
Weizong LiuDepartment of Ultrasound, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen Guangdong, 518035, Guangdong, China. vincentlwz@163.com.

Funding

Clinical Research Program of Shenzhen Second People's Hospital No. 2023yjlcyj014Huizhou Science and Technology Program, China No. 2024CZ010130Medical Scientific Research Foundation of Guangdong Province, China No. A2023246Shenzhen Science and Technology Program, China No. JCYJ20220530150801002, RCBS20221008093242056
6 · The paper itself

Abstract

objectivesTo evaluate the safety and efficacy of ultrasound (US)-guided microwave ablation (MWA) for inactivating excess remnant thyroid (RT) after surgery in patients with differentiated thyroid cancer (DTC).

methodsThis study was registered in the Chinese Clinical Trial Registry under the identifier ChiCTR2200063200 on September 1, 2022. This study enrolled consecutive postsurgery DTC patients who were scheduled for radioactive iodine ablation (RAI) therapy. These patients exhibited excess RT, which was removed via MWA. Changes in RT volume/weight before and after MWA, as well as alterations in laboratory parameters, were assessed. Complications arising from MWA were documented and monitored.

resultsTwenty-three patients participated in the study. Following US-guided MWA, there was a statistically significant decrease in the volume/weight of RT, from [2.90 (1.78, 4.28)] mL/[2.66 (1.63, 3.92] g to (0.93 ± 0.43) mL/(0.83 ± 0.40) g (P < 0.001). Nineteen patients had an RT weight < 1 g post-MWA. An observed threshold effect between TSH levels and post-MWA follow-up time revealed an inflection point at 17.0 days, with TSH levels increasing by 2.5 mU/L per day from 0 to 17.0 days (P < 0.001), peaking above 30 mU/L on day 17.0. The TSH level subsequently decreased by 1.6 mU/L per day (P = 0.028) after 17.0 days. No serious complications were noted.

conclusionsUS-guided MWA is a relatively safe and effective method for inactivating excess RT after surgery and represents a potentially innovative minimally invasive approach. The relationship between TSH and follow-up time after MWA for inactivating excess RT reveals a threshold effect, aiding in determining the optimal timing for RAI therapy post-MWA, yet its universal applicability necessitates additional investigation.

Indexed as

Ablation TechniquesMicrowavesRadiofrequency AblationThyroid GlandThyroid NeoplasmsAdultAgedFemaleHumansIodine RadioisotopesMaleMiddle AgedPilot ProjectsThyroidectomyTreatment OutcomeUltrasonographyIodine RadioisotopesMicrowave ablationRadioactive iodine ablationRemnant thyroidThyroid cancerUltrasound

Identifiers

PMID40087677
PMCPMC11908029

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.