ArticleThrombosis journal2025
Characteristics, management and outcomes of central versus peripheral pulmonary embolism: a retrospective cohort study.
Article in Thrombosis journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Evaluation of the relationship between thrombus burden, inflammation indices, and prognosis in central and peripheral pulmonary embolism.Thrombosis journal · 2026Article
- Clinical Profile and Admission Outcomes of Patients With Acute Pulmonary Embolism at a Resource-Constrained Hospital in Ghana: A Retrospective Pilot Study.Health science reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe location of thrombus in acute pulmonary embolism (PE) is a debatable prognostic factor. We compared the characteristics and outcomes of hospitalized patients with central versus peripheral PE.
methodsThis retrospective study evaluated patients with acute PE diagnosed by CT pulmonary angiography who were hospitalized between 01/01/2016 and 31/12/2022. We compared patients with central (pulmonary trunk/main pulmonary artery) and peripheral (lobar/segmental/subsegmental) PE.
resultsWe studied 438 patients (median age: 63 years; PE diagnosis in the Emergency Department: 64.8%; PE peripheral in 305 patients [69.6%] and central in 133 [30.4%]). Patients with central PE had higher levels of troponin I and brain natriuretic peptide and more frequent right ventricular strain by CT pulmonary angiography/ echocardiography (72.1% versus 33.3%, p < 0.0001). PE mortality risk could be classified in 355 patients; 24.4% of the 238 patients with peripheral PE were intermediate-high/ high-risk compared with 63.3% of the 117 patients with central PE. Patients with central PE had more systemic thrombolysis (13/133 [9.8%] versus 6/305 [2.0%], p < 0.0001) and more advanced endovascular therapy (15/133 [11.3%] versus 2/305 [0.7%], p < 0.0001). All-cause hospital mortality rate was similar in patients with central and peripheral PE (5.3% and 6.6%, respectively; p = 0.61). On multivariable logistic regression analysis, central versus peripheral PE was not associated with hospital mortality (odds ratio 0.392, 95% confidence interval 0.128, 1.199).
conclusionsThe majority of patients with central PE and a minority of those with peripheral PE were classified as intermediate-high/ high-risk, however, the central thrombus location was not associated with an increased risk of mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.