Observational studyBMC neurology2025
Cognition, mental health, and quality of life in patients with chronic and episodic migraine during the interictal period.
Observational study in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The mechanism of different microglial receptors mediating central inflammation in chronic migraine: a meta-analysis.The journal of headache and pain · 2026Pooled it
- Investigating the impact of migraine on short-term and working memory: a systematic review and meta-analysis.Journal of neurology · 2026Pooled it
- The MIND Study: Design, Feasibility, and Baseline Characteristics of a Smartphone-Based Migraine Cohort.medRxiv : the preprint server for health sciences · 2026Article
- Interictal and Ictal Cognitive Performance in Episodic and Chronic Migraine.European journal of neurology · 2026Article
- Impact of migraine on quality of life and disability: a matched cross-sectional comparative study in a tertiary hospital in Malaysia.Frontiers in neurology · 2026Article
- 5.0 T MRI reveals characteristic alterations in visual and somatomotor networks associated with migraine chronification: a single-center prospective cohort study.The journal of headache and pain · 2025Article
- Volumetric analysis of hippocampal subregions in migraine without aura: an exploratory study on mechanisms underlying migraine chronification.The journal of headache and pain · 2025Article
- Migraine Among University Students: Prevalence, Characteristics, and Sociodemographic Influences.Healthcare (Basel, Switzerland) · 2025Article
- Efficacy of acupuncture for chronic migraine: a protocol for a multicenter randomized controlled trial.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionMigraine is a highly prevalent and disabling condition, not only due to its painful symptoms but also because of its significant impact on mental health and cognitive functioning, leading to a considerable deterioration in quality of life. This study aimed to evaluate the cognitive profile, mental health, and quality of life in patients with chronic and episodic migraine during the interictal period, and to explore their relationship with sociodemographic and clinical variables.
methodThis observational, descriptive, cross-sectional analytical study included 60 patients diagnosed with chronic or episodic migraine, who were enrolled in a health program for headache patients between 2010 and 2016. Cognitive function, anxiety and/or depression symptoms, and quality of life during the interictal period were assessed. Descriptive analyses were conducted, and associations were evaluated by configuring primary (type of migraine) and alternative events (cognitive impairment, depression and/or anxiety, and poor quality of life).
resultsThe mean age of the participants was 45 years (SD ± 8), with 83.3% being women and 93.3% belonging to middle and low socioeconomic strata. Of the 60 patients, 83.3% (50) were diagnosed with chronic migraine, while the remaining had episodic migraine. The use of one or more cognition-altering medications was observed in 90% of patients with chronic migraine and 60% of those with episodic migraine (p = 0.02). Anxiety was more prevalent in patients with episodic migraine, whereas depression was more common among those with chronic migraine. Female gender, middle socioeconomic status, and longer disease duration were significantly associated with chronic migraine. Among the 57 patients who completed the Mini-Mental State Examination, 38.6% had cognitive impairment, which decreased with longer migraine duration and better social interaction. Memory and selective attention were the most affected cognitive domains in both groups. No significant associations were found for the other variables after adjusting for confounders.
conclusionsChronic migraine significantly impacts mental health, cognition, and quality of life, with depression and cognitive impairments being prevalent. Social interaction and longer disease duration may protect against cognitive decline, highlighting the need for multidisciplinary, personalized interventions addressing neurological and psychosocial challenges.
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