Evidence map›Paper›PMID 40087588›Full record

ArticleBMC geriatrics2025

Visual impairment predicts greater declines in physical performance over time: the Health, Aging and Body Composition Study.

Atalie C Thompson, Michael E Miller, Christopher Webb, Jeff D Williamson, Stephen B Kritchevsky

Abstract readMulticenter Study
In one paragraph

Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Atalie C ThompsonDepartment of Surgical Ophthalmology, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston Salem, NC, 27157, USA. atathomp@wakehealth.edu.
Michael E MillerDivision of Public Health Sciences, Wake Forest University School of Medicine, 475 Vine Street, Winston Salem, NC, 27101, USA.
Christopher WebbDivision of Public Health Sciences, Wake Forest University School of Medicine, 475 Vine Street, Winston Salem, NC, 27101, USA.
Jeff D WilliamsonDivision of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, 475 Vine Street, Winston Salem, NC, 27101, USA.
Stephen B KritchevskyDivision of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, 475 Vine Street, Winston Salem, NC, 27101, USA.

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
Deep learning to quantify glaucomatous damage on fundus photographs for teleophthalmologyK23EY030897 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI THOMPSON, ATALIE C · 2020 to 2024
$968k
NEI NIH HHS 5K23EY030897NEI NIH HHS K23 EY030897NIA NIH HHS AG021332NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG072947
6 · The paper itself

Abstract

backgroundPoor vision has been associated with physical dysfunction and falls in older adults, but it is not known whether particular types of visual impairment (VI) may predict greater rates of decline in mobility over time in older adults.

methodsMulti-center longitudinal cohort study of 2219 older adults (mean age = 75.5 years; 52.4% female; 37.4% black) who completed self-reported (visual function questions (VFQ)) or performance-based (visual acuity (VA); log contrast sensitivity (LCS); stereoacuity (SA)) vision testing at year 3 and the short physical performance battery (SPPB) at year 4. Analyses were performed including all 2219 participants (Cohort A) and 1795 of these participants with SPPB ≥ 9 (Cohort B) at year 4. Separate linear mixed models were constructed to evaluate the relationship of each vision measure with rate of change in performance on the SPPB and its components (gait speed, balance time, and chair pace) over 8 years.

resultsIn cohort A, compared to the predicted decline at the mean vision level, a significantly faster rate of decline in SPPB was experienced by those with a 1 standard deviation worse year 3 logMAR VA (-0.044; 95% CI -0.065, -0.024), LCS (-0.062; 95% CI -0.082, -0.041), and VFQ (-0.045; 95% CI -0.065, -0.025) and those with a SA > 85 arcsec (-0.095; 95% CI -0.139, -0.052) versus those with SA ≤ 85 (all p < 0.001 for difference in slopes). Cohort B showed similar but stronger findings for SPPB, and demonstrated that worse logMAR VA, LCS and VFQ were significantly associated with a faster decline in gait speed, while worse logMAR VA, LCS, and SA were significantly associated with greater decline in balance times. Only poor SA > 85 arcsec was significantly associated with declines in chair pace.

conclusionsAll VI measures predicted faster declines in SPPB. Older adults with VI may benefit from targeted intervention to prevent declines in mobility.

Indexed as

AgingBody CompositionPhysical Functional PerformanceVision DisordersAgedAged, 80 and overCohort StudiesFemaleHumansLongitudinal StudiesMalePredictive Value of TestsTime FactorsVisual AcuityBalanceContrast sensitivityGaitShort physical performance batteryVisual impairment

Identifiers

PMID40087588
PMCPMC11909918

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.