Evidence map›Paper›PMID 40087579›Full record

ArticleJournal of neurodevelopmental disorders2025

Disrupted visual attention relates to cognitive development in infants with Neurofibromatosis Type 1.

Jannath Begum-Ali, Luke Mason, Tony Charman, Mark H Johnson, Jonathan Green, Shruti Garg, Emily J H Jones, and the STAARS and EDEN Teams

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Article in Journal of neurodevelopmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jannath Begum-AliCentre for Brain and Cognitive Development, School of Psychological Sciences, Faculty of Science, Henry Wellcome Building, Birkbeck, University of London, Malet Street, London, UK. jannath.begum.ali@bbk.ac.uk.ORCID http://orcid.org/0000-0002-8853-0537
Luke MasonDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King'S College London, London, UK.
Tony CharmanDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King'S College London, London, UK.
Mark H JohnsonCentre for Brain and Cognitive Development, School of Psychological Sciences, Faculty of Science, Henry Wellcome Building, Birkbeck, University of London, Malet Street, London, UK.
Jonathan GreenDivision of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.
Shruti GargDivision of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.
Emily J H JonesCentre for Brain and Cognitive Development, School of Psychological Sciences, Faculty of Science, Henry Wellcome Building, Birkbeck, University of London, Malet Street, London, UK. e.jones@bbk.ac.uk.
and the STAARS and EDEN Teams

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeurofibromatosis Type 1 is a genetic condition diagnosed in infancy that substantially increases the likelihood of a child experiencing cognitive and developmental difficulties, including Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD). Children with NF1 show clear differences in attention, but whether these differences emerge in early development and how they relate to broader difficulties with cognitive and learning skills is unclear. To address this question requires longitudinal prospective studies from infancy, where the relation between domains of visual attention (including exogenous and endogenous shifting) and cognitive development can be mapped over time.

methodsWe report data from 28 infants with NF1 tested longitudinally at 5, 10 and 14 months compared to cohorts of 29 typical likelihood infants (with no history of NF1 or ASD and/or ADHD), and 123 infants with a family history of ASD and/or ADHD. We used an eyetracking battery to measure both exogenous and endogenous control of visual attention.

resultsInfants with NF1 demonstrated intact social orienting, but slower development of endogenous visual foraging. This slower development presented as prolonged engagement with a salient stimulus in a static display relative to typically developing infants. In terms of exogenous attention shifting, NF1 infants showed faster saccadic reaction times than typical likelihood infants. However, the NF1 group demonstrated a slower developmental improvement from 5 to 14 months of age. Individual differences in foraging and saccade times were concurrently related to visual reception abilities within the full infant cohort (NF1, typical likelihood and those with a family history of ASD/ADHD).

conclusionsOur results provide preliminary evidence that alterations in saccadic reaction time and visual foraging may contribute to learning difficulties in infants with NF1.

Indexed as

AttentionChild DevelopmentCognitionNeurofibromatosis 1Visual PerceptionAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderFemaleHumansInfantLongitudinal StudiesMaleAttention deficit hyperactivity disorderAutism spectrum disorderEye trackingLongitudinalNeurofibromatosis Type 1Visual attention

Identifiers

PMID40087579
PMCPMC11907931

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.