ArticleScientific reports2025
Prognostic value of combined NP and LHb index with absolute monocyte count in colorectal cancer patients.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Application of indocyanine green fluorescence-guided laparoscopic hepatectomy in patients with liver metastases: a retrospective single‑center study.BMC surgery · 2026Article
- Cycloastragenol Inhibits Colorectal Cancer Cell Metastasis via Epithelial-Mesenchymal Transition and the PI3K Signalling Pathway.Journal of cellular and molecular medicine · 2026Article
- Isotopically enrichedScientific reports · 2026Article
- Qoppa as a New Pan-Tumor Synthetic Parameter Derived from Tumor-Associated Biomarkers for Identifying Oncology Patients at High Risk of Metastasis: A Prospective Pilot Study.Journal of clinical medicine · 2026Article
- G-CSF promotes H3K27ac-modified KLF5 to activate CXCR4 expression and drive colon cancer growth and metastasis.European journal of medical research · 2026Article
- Effect of chemotherapy on gut microbiota in patients with colorectal cancer.Frontiers in microbiology · 2026Article
- Comprehensive analysis of m6A RNA methylation regulators for prognostic risk stratification and immune microenvironment characterization in colorectal cancer.Open medicine (Warsaw, Poland) · 2026Article
- Causal associations among albumin, C-reactive protein, body mass index, and the risk of colorectal cancer.Discover oncology · 2025Article
- Identify novel molecular subtypes of lung adenocarcinoma to predict treatment response and prognosis.Scientific reports · 2025Article
- Development of a novel nomogram to predict the prognosis of acute pancreatitis in pregnancy.BMC gastroenterology · 2025Article
- Regulation of carbonic anhydrase IX gene expression through the LncRNA TRPM2-AS is associated with tumor progression in colorectal tumors.Discover oncology · 2025Article
- Erythrocyte lifespan for predicting moderate and severe anemia in advanced gastric cancer patients post-anti-tumor therapeutics: a prospective study.BMC cancer · 2025Article
- Risk factors and predictive model of lymph node metastasis in clinical stage IA peripheral non-small cell lung cancer: a retrospective study.BMC cancer · 2025Article
- FAM3B overexpression correlates with poor prognosis and immune dysregulation in colorectal cancer: insights from bioinformatics and Mendelian randomization analyses.Discover oncology · 2025Article
- Unveiling the significance of ADAM12 through pan-cancer analysis and experimental verification in gastric cancer.Discover oncology · 2025Article
- Trends in pancreatic cancer mortality among US adults, 1999-2023.BMC gastroenterology · 2025Article
- Characteristics and risk factors for thrombocytopenia in malignancy patients with pulmonary embolism: a case control study.BMC pulmonary medicine · 2025Article
- Clinical significance of preoperative serum VEGF in predicting metachronous liver metastasis of colorectal cancer: development of a novel nomogram.World journal of surgical oncology · 2025Article
- Application value of indocyanine green fluorescence imaging in assessing blood supply during laparoscopic radical resection of rectal cancer.Experimental and therapeutic medicine · 2025Article
- FAM49B mediates tumor progression and poor prognosis of gastric cancer through activating PI3K/AKT pathway.Journal of molecular histology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with high postoperative recurrence and metastasis rates posing significant challenges to patient survival. Identifying reliable and accessible prognostic markers is essential for optimizing treatment strategies. This study investigates the prognostic significance of two preoperative hematological indices, the [neutrophils × platelets]/[lymphocytes × hemoglobin] (NP/LHb) ratio and absolute monocyte count (Mono), in predicting overall survival in CRC patients. A retrospective analysis of 566 patients was conducted, with one cohort serving as an external validation set. Receiver operating characteristic curve analysis identified optimal cut-off values for NP/LHb and Mono, and Kaplan-Meier survival analysis revealed that higher levels of both markers were associated with significantly shorter survival. A novel prognostic model, NPM, integrating NP/LHb and Mono, demonstrated superior predictive accuracy compared to either marker alone. The NPM model was further validated through a nomogram, achieving high predictive performance for 1-, 3-, and 5-year survival. These findings highlight the potential of combining inflammatory and nutritional markers for effective risk stratification in CRC patients. The NPM model offers a simple, cost-effective prognostic tool that may facilitate personalized postoperative management, though further prospective validation is warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.