ArticleNature medicine2025
Social disadvantage accelerates aging.
Article in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Liver-specific phenotypic aging, behavior and genetic risks, and long-term liver-related outcomes.GeroScience · 2026Article
- Associations Between Accelerometer-Assessed Sleep Patterns, Proteomic Signatures, and Hallmarks of Aging in Adulthood.Aging cell · 2026Article
- Biological aging clocks in health and disease.Nature medicine · 2026Review
- Non-Invasive Measures of DNA Methylation Capture Molecular Aging in Wild Capuchin Monkeys.Molecular ecology · 2026Article
- Neighborhood opportunity and cellular senescence in a national sample of U.S. adults.Social science & medicine (1982) · 2026Article
- Association between pace of aging estimated from blood DNA methylation and all-cause mortality: the HUNT study.Clinical epigenetics · 2026Article
- Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging.Nature aging · 2026Article
- Remembrance of things past: Towards a life-course biology of aging.PLoS biology · 2026Article
- Incorporating polygenic risk scores and social determinants of health across populations: Considerations and best practices in research.American journal of human genetics · 2026Review
- Aging is not a disease: an evolutionary and comparative biological reappraisal.Biogerontology · 2026Review
- Nurses as guardians of time: the hidden clinical value of continuous care in geriatrics.Frontiers in public health · 2026Review
- Age-Related Human Adaptation to Extreme Climatic Factors and Environmental Conditions.Biology · 2025Article
- Is accelerated biological aging the hidden link between physical frailty, social deficits, cognitive impairment and risk of incident diseases?The journal of nutrition, health & aging · 2025Article
- Ancestry-associated social and genomic hallmarks linked with inferior outcome in elderly acute myeloid leukemia.BMC cancer · 2025Article
- Eight decades of follow-up link life course exposures to proteomic organ ageing and longevity.medRxiv : the preprint server for health sciences · 2025Article
- The X-Age Project to construct a Chinese aging clock.Nature aging · 2025Review
- Life Expectancy and Health Expectancy in the Twenty-first Century: The Unthinkable, the Inconceivable, and the Unknowable.Demography · 2025Article
- Toward precision interventions and metrics of inflammaging.Nature aging · 2025Review
- The Rab3 family proteins in age-related neurodegeneration: unraveling molecular pathways and potential therapeutic targets.npj aging · 2025Review
- Ageing Trajectories: Exposome-Driven Pathobiological Mechanisms and Implications for Prevention from Blue Zones and Italian Longevity Hotspots Such as Cilento and Sicilian Mountain Villages.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Social disadvantage, like advanced age, is a risk factor for a broad range of health conditions; however, whether it influences the aging process remains unclear. Here, using a multicohort approach, we investigated the associations of social disadvantage with age-related plasma proteins and age-related diseases. We found proteomic signatures of accelerated immune aging and 14 specific age-related proteins linked to social disadvantage during both early and later life. Individuals experiencing social disadvantage had an increased risk of 66 age-related diseases, with up to 39% of these associations mediated by the 14 age-related proteins (for example, DNAJB9, F2, HSPA1A, BGN). The main enriched pathway involved the upregulation of the pro-inflammatory regulator NF-κB24 and its downstream factor interleukin-8. Our findings support the hypothesis that social disadvantage throughout the life course may accelerate aging, a biological mechanism that could explain why social stratification plays such a fundamental role in determining human health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.