ArticleScientific reports2025
Enhancing solubility and dissolution of felodipine using self-nanoemulsifying drug systems through in vitro evaluation.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Supercritical COChemical engineering journal advances · 2026Article
- Hot-Melt Processed Glibenclamide Glassy Solutions: A Novel Oral Delivery Platform for Enhanced Bioavailability in Diabetes.Pharmaceutics · 2026Article
- Enhanced Oral Bioavailability of Felodipine via Solid Self-microemulsion Delivery System.AAPS PharmSciTech · 2026Article
- Effect of Surfactants on Oral Delivery of Nanoemulsions Containing Fexofenadine, a Substrate for P-glycoprotein.AAPS PharmSciTech · 2025Article
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Authors and funding
11 authors.
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Abstract
The main objective of the present study was to improve the solubility and dissolution rate of felodipine (FLD), a drug that does not dissolve well in water, using a self-nanoemulsifying drug delivery system (SNEDDS). Many analyses have been performed in the laboratory using different oils, non-ionic surfactants, and water-soluble co-solvents to prepare FLD-loaded SNEDDS. It involves measurements of viscosity, refractive index, and droplet size. Solubility studies revealed the best way to load drugs, and pseudo-ternary phase diagrams showed the right amounts of surfactant and co-surfactant for preparing the nanoemulsion. An in vitro dissolution study showed that SNEDDS worked better than pure FLD, releasing over 95% of FLD within 20 min. SNEDDS loaded with felodipine are a good option for developing new oral medicines because they can hold more drugs, dissolve better, and dissolve more quickly. This new SNEDDS technology shows promise for improving the performance of drugs that do not dissolve well, which could lead to better therapeutic results.
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