Evidence map›Paper›PMID 40087268›Full record

ArticleNature communications2025

Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization.

Yasmyn E Winstanley, Ryan D Rose, Alexander P Sobinoff, Linda L Wu, Deepak Adhikari, Qing-Hua Zhang, Jadon K Wells, Lee H Wong, Hazel H Szeto, Sandra G Piltz and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. NADCommunications biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yasmyn E WinstanleyRobinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0002-0196-0965
Ryan D RoseRobinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0001-9732-1713
Alexander P SobinoffTelomere Length Regulation Unit, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, NSW, Australia.ORCID http://orcid.org/0000-0001-6679-5211
Linda L WuRobinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, SA, Australia.
Deepak AdhikariDevelopment and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-3404-8753
Qing-Hua ZhangDevelopment and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.
Jadon K WellsTelomere Length Regulation Unit, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, NSW, Australia.ORCID http://orcid.org/0009-0007-4809-827X
Lee H WongDepartment of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne VIC, Australia.ORCID http://orcid.org/0000-0002-4005-7330
Hazel H SzetoSocial Profit Network, Menlo Park, CA, 94025, USA.ORCID http://orcid.org/0000-0003-4021-5076
Sandra G PiltzRobinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0003-3386-8140
Paul Q ThomasRobinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0002-5002-5770
Mark A FebbraioMonash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0002-9296-4418
John CarrollDevelopment and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-9644-5861
Hilda A PickettTelomere Length Regulation Unit, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, NSW, Australia.ORCID http://orcid.org/0000-0002-9840-4841
Darryl L RussellRobinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0002-4930-7658
Rebecca L RobkerRobinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, SA, Australia. Rebecca.robker@adelaide.edu.au.ORCID http://orcid.org/0000-0002-1538-4604

Funding

Channel 7 Children's Research Foundation (CRF) 20669397Department of Health | National Health and Medical Research Council (NHMRC) APP1117975Department of Health | National Health and Medical Research Council (NHMRC) APP1130364Department of Health | National Health and Medical Research Council (NHMRC) APP1194141
6 · The paper itself

Abstract

The initial setting of telomere length during early life in each individual has a major influence on lifetime risk of aging-associated diseases; however there is limited knowledge of biological signals that regulate inheritance of telomere length, and whether it is modifiable is not known. We now show that when mitochondrial activity is disrupted in mouse zygotes, via exposure to 20% O

Indexed as

Cell NucleusFertilizationMitochondriaTelomereTelomere HomeostasisAnimalsBlastocystFemaleMaleMetforminMiceMice, Inbred C57BLPregnancyRotenoneUbiquinoneZygoteMetforminRotenoneUbiquinone

Identifiers

PMID40087268
PMCPMC11909127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.