Evidence map›Paper›PMID 40087194›Full record

ArticleAAPS PharmSciTech2025

Brazilian Green Propolis Extract-Loaded Poly(Ε-Caprolactone) Nanoparticles Coated with Hyaluronic Acid: Antifungal Activity in a Murine Model of Vulvovaginal Candidiasis.

Aniely Dos Reis Teixeira, Amanda De Vasconcelos Quaresma, Renata Tupinambá Branquinho, Patrícia Capelari De Oliveira, Jorge Andrés García Suárez, Geraldo Célio Brandão, Ana Paula Moreira Barboza, Marcelo Gonzaga De Freitas Araújo, Juliana Teixeira De Magalhães, Sandra Aparecida Lima De Moura and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in AAPS PharmSciTech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aniely Dos Reis TeixeiraSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
Amanda De Vasconcelos QuaresmaSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
Renata Tupinambá BranquinhoSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
Patrícia Capelari De OliveiraSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
Jorge Andrés García SuárezSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
Geraldo Célio BrandãoSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
Ana Paula Moreira BarbozaDepartment of Physics, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
Marcelo Gonzaga De Freitas AraújoSchool of Pharmacy, Federal University of São João del-Rei, Divinópolis, Minas Gerais, 35501-296, Brazil.
Juliana Teixeira De MagalhãesSchool of Pharmacy, Federal University of São João del-Rei, Divinópolis, Minas Gerais, 35501-296, Brazil.
Sandra Aparecida Lima De MouraDepartment of Environmental Engineering, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
Gisele Rodrigues Da SilvaSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil. giselersilva@ufop.edu.br.ORCID http://orcid.org/0000-0001-5920-3521

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brazilian green propolis extract-loaded poly(ε-caprolactone) nanoparticles coated with hyaluronic acid (PE-NPsHA) were developed as a therapeutic strategy to treat vulvovaginal candidiasis (VVC) and combat the growing issue of fungal resistance. The chemical composition of PE was analyzed using UHPLC-MS/MS, revealing the presence of various bioactive compounds, such as phenolic acids, flavonoids, coumarins, and quinones. These compounds were encapsulated into the polymeric matrix of NPs, as indicated by FTIR and DSC. In addition, PE-NPsHA were characterized by DLS, AFM, encapsulation efficiency (EE), and in vitro release study. They displayed a spherical morphology with a hydrodynamic diameter of 170 nm, a low polydispersity index of 0.1, a zeta potential of -28.5 mV, and an EE of 78%. The in vitro release study indicated a controlled and sustained release of PE over a period of 96 h. The in vitro and in vivo PE-NPsHA biocompatibility were investigated as well as their antifungal activity in a murine model of VVC. PE-NPsHA did not impact the HaCaT cell viability and demonstrated no signs of in vivo vaginal toxicity. PE-NPsHA exhibited in vivo antifungal efficacy, effectively eliminating Candida albicans infection. PE-NPsHA could expand the available treatment options for VVC and counteract Candida resistance to antifungal drugs.

Indexed as

Antifungal AgentsCandidiasis, VulvovaginalHyaluronic AcidNanoparticlesPolyestersPropolisAnimalsBrazilCandida albicansCell SurvivalDisease Models, AnimalDrug CarriersDrug LiberationFemaleHaCaT CellsHumansAntifungal AgentsDrug CarriersHyaluronic AcidpolycaprolactonePolyestersPropolisBrazilian green propolis extractFungal resistanceHyaluronic acid coatingPoly(ε-caprolactone) nanoparticlesVulvovaginal candidiasis (VVC)

Identifiers

PMID40087194

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.