Evidence map›Paper›PMID 40087158›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Association of Menière's disease with depression and anxiety: a systematic review and meta-analysis.

Brian Sheng Yep Yeo, Emma Min Shuen Toh, Nicholas E-Kai Lim, Rachel Siying Lee, Roger Chun Man Ho, Wilson Wai San Tam, Raymond Yeow Seng Ngo

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Intratympanic corticosteroid injection for Ménière's disease: systematic review of randomized controlled trials.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brian Sheng Yep Yeo *Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Emma Min Shuen Toh *Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Nicholas E-Kai LimYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Rachel Siying LeeYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Roger Chun Man HoDepartment of Psychological Medicine, National University Hospital, Singapore, Singapore.
Wilson Wai San TamAlice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Raymond Yeow Seng NgoDepartment of Otolaryngology-Head and Neck Surgery, Ng Teng Fong General Hospital, Singapore, Singapore. entnysr@nus.edu.sg.ORCID http://orcid.org/0000-0002-3328-8624

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe persistent and recurring nature of Menière's Disease may pose psychological challenges for patients. The association between Menière's Disease and depression and anxiety remains inconclusive among pre-existing studies. This study seeks to review and synthesise existing evidence regarding the association between Menière's Disease and depression and anxiety.

methodsTwo authors independently searched PubMed, Embase and The Cochrane Library for observational or randomized studies investigating the association between Menière's Disease with depression or anxiety. Using a random-effects model, the prevalence of depression and anxiety among Menière's Disease patients were pooled using proportions, the standardized mean difference of depression and anxiety test scores between Menière's Disease patients and controls were compared, and maximally-adjusted risk ratios were pooled to determine the risk of depression and anxiety. Heterogeneity was assessed using the I

resultsWe included 35 observational studies with 15,890 patients. The prevalence of depression and anxiety among Menière's Disease patients were 34% (95% CI 18%-54%) and 23% (95% CI 16%-32%) respectively. Patients with Menière's Disease exhibited significantly elevated scores in both depression (SMD: 0.73, 95% CI 0.22-1.25) and anxiety (SMD: 0.687, 95% CI 0.228-1.146) assessments in comparison to healthy controls. However, no significant correlation was observed between Menière's Disease and the long-term risk of developing depression or anxiety.

conclusionThere may be an association between Menière's Disease and depression and anxiety, but further studies are required to confirm these findings.

Indexed as

AnxietyDepressionMeniere DiseaseHumansPrevalenceAnxietyDepressionMenière’s diseaseMeta-analysisSystematic review

Identifiers

PMID40087158

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.