Evidence map›Paper›PMID 40086876›Full record

ArticleGenes & development2025

Developmentally regulated proteolysis by MdfA and ClpCP mediates metabolic differentiation during

Eammon P Riley, Jelani A Lyda, Octavio Reyes-Matte, Joseph Sugie, Iqra R Kasu, Eray Enustun, Emily G Armbruster, Sumedha Ravishankar, Rivka L Isaacson, Amy H Camp and 2 more

Abstract read
In one paragraph

Article in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Eammon P Riley *School of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA.ORCID http://orcid.org/0000-0003-4960-7578
Jelani A Lyda *School of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA.ORCID http://orcid.org/0000-0001-6798-2844
Octavio Reyes-MatteMax Planck Institute for Evolutionary Biology, Plön 24306, Germany.
Joseph SugieSchool of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA.ORCID http://orcid.org/0000-0003-2911-1807
Iqra R KasuMax Planck Institute for Evolutionary Biology, Plön 24306, Germany.
Eray EnustunSchool of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA.ORCID http://orcid.org/0000-0001-7550-7752
Emily G ArmbrusterSchool of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA.ORCID http://orcid.org/0000-0003-0377-1209
Sumedha RavishankarSchool of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA.ORCID http://orcid.org/0000-0002-4026-0742
Rivka L IsaacsonDepartment of Chemistry, King's College London, London WC2R 2LS, United Kingdom.ORCID http://orcid.org/0000-0002-9978-8904
Amy H CampDepartment of Biological Sciences, Mount Holyoke College, South Hadley, Massachusetts 01075, USA.ORCID http://orcid.org/0000-0002-2398-6402
Javier Lopez-GarridoMax Planck Institute for Evolutionary Biology, Plön 24306, Germany; kpogliano@ucsd.edu lopezgarrido@evolbio.mpg.de.ORCID http://orcid.org/0000-0002-8907-502X
Kit PoglianoSchool of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA; kpogliano@ucsd.edu lopezgarrido@evolbio.mpg.de.ORCID http://orcid.org/0000-0002-7868-3345

Funding

GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8M
Pathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9M
FORESPORE ENGULFMENT DURING B SUBTILIS SPORULATIONR01GM057045 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POGLIANO, KIT J · 1998 to 2021
$6.1M
Identification of natural products targeting new pathways in bacteriaR01AI113295 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POGLIANO, JOSEPH A, POGLIANO, KIT J · 2014 to 2018
$3.3M
A Feeding Tube Model for Bacterial Cell-Cell CommunicationDP2GM105439 · NIGMS · MOUNT HOLYOKE COLLEGE · PI CAMP, AMY HITCHCOCK · 2012 to 2012
$2.1M
NIAID NIH HHS R01 AI113295NIGMS NIH HHS DP2 GM105439NIGMS NIH HHS R01 GM057045NIGMS NIH HHS T32 GM007240NIGMS NIH HHS T32 GM133351
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

metabolic reprogrammingmetabolismoxidative stressproteolysissporulation

Identifiers

PMID40086876
PMCPMC11960778

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.