Evidence map›Paper›PMID 40086867›Full record

ArticleThe British journal of ophthalmology2025

Comparison of structure-function correlation among IMO visual function analyser and Humphrey field analyser.

Joyce Kang, Rafaella Nascimento E Silva, Julia Anne Kim, Dolly Chang, Yihao Li, Chen Chen, Yan Zhao, Sofia De Arrigunaga, Sandra E Freeman, Tobias Elze and 2 more

Abstract readComparative Study
In one paragraph

Article in The British journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joyce KangMassachusetts Eye and Ear, Boston, Massachusetts, USA.
Rafaella Nascimento E SilvaGenentech Inc, South San Francisco, California, USA.
Julia Anne KimGenentech Inc, South San Francisco, California, USA.
Dolly ChangGenentech Inc, South San Francisco, California, USA.
Yihao LiGenentech Inc, South San Francisco, California, USA.
Chen ChenGenentech Inc, South San Francisco, California, USA.
Yan ZhaoHarvard Medical School, Boston, Massachusetts, USA.
Sofia De ArrigunagaGlaucoma Center of Excellence, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
Sandra E FreemanGlaucoma Center of Excellence, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
Tobias ElzeRetina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
Michael M LinGlaucoma, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0001-8739-4329
David S FriedmanGlaucoma Center of Excellence, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA Friedman@meei.harvard.edu.ORCID http://orcid.org/0000-0002-2055-5797

Funding

VISION RESEARCHP30EY003790 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Patricia Ann D'Amore · 1985 to 2026
$25.5M
Personalizing Glaucoma Diagnosis by Disease Specific Patterns and Individual Eye AnatomyR01EY030575 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI ELZE, TOBIAS · 2019 to 2023
$2.4M
NEI NIH HHS P30 EY003790NEI NIH HHS R01 EY030575
6 · The paper itself

Abstract

purposeTo compare the structure-function correlations between optical coherence tomography (OCT) thickness parameters and the corresponding sectorial mean sensitivity (MS) values obtained with IMO visual function analyser (IMOvifa) and Humphrey field analyser (HFA) perimeters.

designProspective cross-sectional study.

methodsGlaucoma suspect, glaucoma and ocular hypertension patients underwent IMOvifa 24-2 Ambient Interactive Zippy Estimated Sequential Testing, HFA 24-2 Swedish Interactive Threshold Algorithm-Standard and OCT tests within 12 weeks. Based on the Garway-Heath map, the sensitivity points were divided in corresponding OCT peripapillary retinal nerve fibre layer (pRNFL) sectors, and also the central 10° points in corresponding ganglion cell-inner plexiform layer thickness over the macula. The structure-function correlations were analysed by Spearman's rank coefficient and compared by Steiger's test.

results57 eyes of 57 patients (mean age 59.2 years, 61.4% female) with reliable field and adequate OCT strength were included in this analysis. IMOvifa had significantly shorter testing time (3.7 vs 5.3 mins), lower mean deviation (difference -0.6 dB) and greater visual field index (difference +1.0%) compared with HFA (p<0.001 for all). There was moderate to strong correlation between IMOvifa and HFA MS sectors (p<0.001 for all). IMOvifa had significant correlations in the inferior (I, r=0.46), superior (S, r=0.45), temporal (T, r=0.28) pRNFL sectors and in the I (r=0.63) and S (r=0.53) mGCPIPL hemispheres (p≤0.03 for all). There was no significant difference in the strength of the correlation of IMOvifa versus HFA results with OCT parameters (p≥0.06).

conclusionsThe IMOvifa test took less time and resulted in slightly less severe defects than HFA. MS in all sectors was moderately to strongly correlated. Function-structure correlations were similar when using either perimeter.

Indexed as

GlaucomaOcular HypertensionRetinal Ganglion CellsTomography, Optical CoherenceVisual FieldsVisual Field TestsAdultAgedCross-Sectional StudiesFemaleHumansIntraocular PressureMaleMiddle AgedNerve FibersProspective StudiesDiagnostic tests/InvestigationField of visionGlaucomaOptic NerveProspective Studies

Identifiers

PMID40086867
PMCPMC12421096

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.