Evidence map›Paper›PMID 40086831›Full record

ReviewRNA (New York, N.Y.)2025

Dissecting the stress granule RNA world: dynamics, strategies, and data.

Giulia Biancon, Emma Busarello, Matthew Cheng, Stephanie Halene, Toma Tebaldi

Abstract readReview
In one paragraph

Review in RNA (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Giulia Biancon *Section of Hematology, Department of Internal Medicine, Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA giulia.biancon@yale.edu.ORCID 0000-0003-0182-7766
Emma Busarello *Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, 38123, Italy.ORCID 0009-0009-7731-9777
Matthew ChengSection of Hematology, Department of Internal Medicine, Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA.ORCID 0009-0002-1067-9937
Stephanie Halene *Section of Hematology, Department of Internal Medicine, Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA.ORCID 0000-0002-2737-9810
Toma Tebaldi *Section of Hematology, Department of Internal Medicine, Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA.ORCID 0000-0002-0625-1631

Funding

Targeting Defective DNA Damage Response Pathways in IDH1/2-mutant AMLR01CA266604 · NCI · YALE UNIVERSITY · PI Ranjit Bindra, Stephanie Halene · 2022 to 2026
$3.3M
Mechanisms of Leukemogenesis in AMKLR01CA222518 · NCI · YALE UNIVERSITY · PI HALENE, STEPHANIE, KRAUSE, DIANE S · 2020 to 2024
$3.0M
Modeling myelodysplasiaR01CA253981 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI GRIMES, H. LEIGHTON, HALENE, STEPHANIE · 2021 to 2025
$2.9M
The role of m6A RNA modification as modulator of dsRNA induced cell-intrinsic innate immune responses in hematopoiesisR01DK124788 · NIDDK · YALE UNIVERSITY · PI HALENE, STEPHANIE · 2021 to 2023
$884k
NCI NIH HHS R01 CA222518NCI NIH HHS R01 CA253981NCI NIH HHS R01 CA266604NIDDK NIH HHS R01 DK124788
6 · The paper itself

Abstract

Stress granules (SGs) are cytoplasmic ribonucleoprotein granules that commonly nucleate from the interaction of translationally stalled mRNAs and RNA-binding proteins. SGs are involved in the cellular adaptation to stress conditions participating in the regulation of gene expression and cell signaling. While dysregulation of SG dynamics has been increasingly implicated in human disease, a comprehensive understanding of SG composition, particularly of the RNA component, across various conditions remains elusive. Here, we review the physiological and pathological aspects of SGs, discuss current and future experimental strategies to identify SG components, and provide insights into the SG RNA world through the meta-analysis of 26 human SG transcriptome data sets.

Indexed as

Cytoplasmic GranulesRNAStress GranulesAnimalsHumansRibonucleoproteinsRNA-Binding ProteinsRNA, MessengerStress, PhysiologicalTranscriptomeRibonucleoproteinsRNARNA-Binding ProteinsRNA, Messengerbiomolecular condensatesmembraneless organellesphase separationRNARNP granulesstress granules

Identifiers

PMID40086831
PMCPMC12084887

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.