Evidence map›Paper›PMID 40086748›Full record

ArticleContemporary clinical trials2025

Championing Hypertension Remote Monitoring for Equity and Dissemination (CHARMED): A multi-site factorial randomized controlled trial protocol.

Courtney R Lyles, Elaine C Khoong, Rachel J Stern, Nooshin Abtahi, Anjana E Sharma, Mark J Pletcher, Fan Xia, Faviola Garcia, Nilpa D Shah, Lina Tieu and 2 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06113458 (Comparing Hypertension Remote Monitoring Evaluation Redesign), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06113458 naenrolling by invitationnot on this map

Comparing Hypertension Remote Monitoring Evaluation Redesign

TypeinterventionalSponsorUniversity of California, San FranciscoRan2024 to 2028Enrolled2,500ConditionsHypertensionArmsStandard and One-time Training, Standard and Practice Facilitation, High-intensity and One-time Training, High-intensity and Practice Facilitation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Courtney R LylesCenter for Healthcare Research and Policy, University of California Davis, Davis, CA, USA; Division of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA; UCSF Action Research Center for Health Equity, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA. Electronic address: crlyles@ucdavis.edu.
Elaine C KhoongDivision of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA; UCSF Action Research Center for Health Equity, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA.
Rachel J SternDivision of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA; Ventura County Health Care Agency, Ventura, CA, USA.
Nooshin AbtahiContra Costa Health Services, CA, USA.
Anjana E SharmaUCSF Action Research Center for Health Equity, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA; Department of Family and Community Medicine, University of California San Francisco, San Francisco, CA, USA.
Mark J PletcherDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Fan XiaDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Faviola GarciaDivision of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA; UCSF Action Research Center for Health Equity, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA.
Nilpa D ShahDivision of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA; UCSF Action Research Center for Health Equity, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA.
Lina TieuCenter for Healthcare Research and Policy, University of California Davis, Davis, CA, USA.
Urmimala SarkarDivision of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA; UCSF Action Research Center for Health Equity, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA.
CHARMED consortium

Funding

Designing a Remote Monitoring Intervention for Value & Equity in Hypertension (DRIVE-HTN)K23HL157750 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHOONG, ELAINE · 2021 to 2025
$921k
NHLBI NIH HHS K23 HL157750
6 · The paper itself

Abstract

introductionWe have evidence-based strategies such as remote patient monitoring and digital health tools to improve hypertension outcomes. Still, we lack large-scale studies focusing on disseminating these practices into routine clinical care. This is especially important to study within safety-net healthcare settings that disproportionately care for marginalized patient populations.

methodsWe will conduct a hybrid type 1 implementation trial (2 × 2 factorial design) with 25 safety-net clinics across three of California's public healthcare delivery systems, enrolling 2500 English- and Spanish-speaking patients with uncontrolled hypertension. Clinics will be randomized to receive baseline training on best practices in remote monitoring for hypertension management vs. training plus ongoing practice facilitation to support its implementation. Patients within these clinics will be randomized to receive cellular-enabled blood pressure monitors and automatic text message reminders to check their blood pressure at home vs. receipt of the same monitors as well as additional support via individually tailored text message feedback and support for hypertension management.

resultsThe primary outcome will be a change in systolic blood pressure collected during routine office visits. Secondary outcomes include changes in home blood pressure and patient-reported assessments of clinical care and medication adherence. Given the hybrid type I trial implementation, the primary implementation outcomes will be the adoption of intervention at the patient and clinic levels. DISCUSSION: The evidence from this trial will advance implementation-focused research on hypertension management, such as the essential combination of both patient- and clinic-facing intervention strategies.

trial registrationNCT, NCT06113458. Registered 23 October 2023, https://clinicaltrials.gov/study/NCT06113458.

Indexed as

Blood Pressure Monitoring, AmbulatoryHypertensionAntihypertensive AgentsBlood PressureCaliforniaHumansMulticenter Studies as TopicRandomized Controlled Trials as TopicReminder SystemsSafety-net ProvidersTelemedicineText MessagingAntihypertensive AgentsDigital healthHome blood pressure monitoringHypertensionRemote patient monitoring

Identifiers

PMID40086748
PMCPMC12147860

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.