Evidence map›Paper›PMID 40086718›Full record

ArticleResuscitation2025

Temporalis muscle thickness correlates with premorbid frailty in patients resuscitated from cardiac arrest.

Jonathan Tam, Cecelia Ratay, Laura Faiver, Patrick J Coppler, Micaila Baroffio, Mikaela Mohardt, Nicholas Case, Clifton Callaway, Jonathan Elmer, University of Pittsburgh Post-Cardiac Arrest Service

Abstract read
In one paragraph

Article in Resuscitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonathan TamDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, United States; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, United States. Electronic address: tamjw@upmc.edu.
Cecelia RatayDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, United States.
Laura FaiverDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, United States.
Patrick J CopplerDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, United States.
Micaila BaroffioDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, United States.
Mikaela MohardtDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, United States.
Nicholas CaseDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, United States.
Clifton CallawayDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, United States.
Jonathan ElmerDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, United States; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, United States; Department of Neurology, University of Pittsburgh School of Medicine, United States.
University of Pittsburgh Post-Cardiac Arrest Service

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
NRSA Training CoreTL1TR001858 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RADOMSKI, THOMAS, RUBIO, DORIS M · 2016 to 2025
$11.1M
Multidisciplinary Training in Critical Care Outcomes ResearchT32HL007820 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Timothy D Girard, Jeremy M Kahn · 1996 to 2026
$6.4M
Emergency Medicine Research TrainingT32HL134615 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Clifton W. Callaway, DONALD M YEALY · 2017 to 2026
$2.4M
NCATS NIH HHS TL1 TR001858NCATS NIH HHS UL1 TR001857NHLBI NIH HHS T32 HL007820NHLBI NIH HHS T32 HL134615
6 · The paper itself

Abstract

introductionFrailty is associated with mortality and functional outcome after cardiac arrest. Temporalis muscle thickness (TMT) is a measure of sarcopenia, which represents one dimension of frailty. We assessed the correlation between TMT, measured on head computed tomography (CT), and Clinical Frailty Scale (CFS) in patients resuscitated from cardiac arrest.

methodsWe enrolled adults resuscitated from cardiac arrest who had a head CT obtained within 48 h of collapse. Study investigators prospectively obtained data to determine pre-arrest CFS and blinded investigators measured TMT. We calculated Spearman rank-order correlation to assess the relationship between TMT and CFS. We also performed multivariable regression adjusting for confounders of frailty and sarcopenia.

resultsWe enrolled 50 subjects with median CFS 4 [IQR 2-6] and median TMT 6.6 [IQR 5.0-8.9] mm. There was a moderate, negative correlation between TMT and CFS (ρ = -0.52 (p < 0.001)). In linear regression, TMT (R

conclusionsWe found that TMT exhibits a moderate negative correlation with the CFS, supporting TMT as a tool to measure frailty. Measuring TMT in patients with early head CTs after resuscitation from cardiac arrest may allow for characterization of sarcopenia as a dimension of pre-arrest frailty.

Indexed as

Cardiopulmonary ResuscitationFrailtyHeart ArrestSarcopeniaTemporal MuscleAgedAged, 80 and overFemaleHumansMaleMiddle AgedProspective StudiesTomography, X-Ray ComputedClinical frailty scaleComputed tomographyFrailtyPost-cardiac arrestSarcopeniaTemporalis muscle thickness

Identifiers

PMID40086718
PMCPMC12486771

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.