Evidence map›Paper›PMID 40086419›Full record

ArticleAdvances in life course research2025

Life course socioeconomic position and cognitive aging in later life: A scoping review.

Mengling Cheng, Lore Van Herreweghe, Aswathikutty Gireesh, Stefan Sieber, Kenneth F Ferraro, Stéphane Cullati

Abstract readScoping Review
In one paragraph

Article in Advances in life course research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. MethylCog predicts six-year cognitive ability beyond blood-based ADRD biomarkers.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mengling ChengSchool of Social and Public Administration, East China University of Science and Technology, China; Swiss Centre of Expertise in Life Course Research, University of Lausanne, Switzerland. Electronic address: mengling.cheng@ecust.edu.cn.
Lore Van HerrewegheCentre for Sociological Research, KU Leuven, Belgium.
Aswathikutty GireeshDepartment of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London, United Kingdom.
Stefan SieberSwiss Centre of Expertise in Life Course Research, University of Lausanne, Switzerland; Barcelona Institute for Global Health (ISGlobal), Spain.
Kenneth F FerraroCenter on Aging and the Life Course, Purdue University, United States; Department of Sociology, Purdue University, United States.
Stéphane CullatiSwiss Centre of Expertise in Life Course Research, University of Lausanne, Switzerland; Population Health Laboratory (#PopHealthLab), University of Fribourg, Switzerland.

Funding

Disparities in the Life Course Origins of Cognitive DeclineRF1AG068388 · NIA · PURDUE UNIVERSITY · PI FERRARO, KENNETH F. · 2020 to 2020
$675k
NIA NIH HHS RF1 AG068388
6 · The paper itself

Abstract

BACKGROUND AND

objectivesLow socioeconomic position (SEP) throughout the life course is related to poorer cognitive health in later life, but debate ensues on the life course models for this association. To advance inquiry on the topic, we conducted a scoping review. RESEARCH DESIGN AND

methodsWe examined the association between life course SEP and cognitive function in later life in observational studies-considering cognition both as a cross-sectional level and as a longitudinal trajectory across cognitive domains-and assessed whether the empirical evidence supported life course models. We focused on studies in the general population with cognition measured in the second half of life (45 +). Forty-two studies (21 datasets) were included representing 595,276 participants (201,375 across unique datasets) from 46 countries.

resultsFor cognitive level, studies consistently found associations between SEP at various stages of the life course, both in overall cognition and across specific cognitive domains. These associations were generally robust to confounding and mediating factors. For cognitive trajectory, studies showed inconclusive associations with SEP across life course and across cognitive domains. Results supported the sensitive period, pathway, and accumulation models, but not the critical period model. Results supported that education acts as a pathway (and potential mediator) in the association between early-life SEP and later-life cognition. DISCUSSION AND IMPLICATIONS: SEP throughout the life course has a robust association with later-life cognitive level, but not decline. Early-life cognitive enrichment for young people raised in socioeconomically disadvantaged households may reduce the SEP gap in cognitive functioning during later life.

Indexed as

AgingCognitionCognitive AgingSocial ClassAgedCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedSocioeconomic FactorsAgingCognitionLife courseSocial determinants of healthSocioeconomic position

Identifiers

PMID40086419
PMCPMC12124963

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