ArticleMedical image analysis2025
Imaging the structural connectome with hybrid MRI-microscopy tractography.
Article in Medical image analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Microscopy-informed structural connectivity mapping in the in vivo human brain via domain adaptation.bioRxiv : the preprint server for biology · 2026Article
- Diffusion-weighted steady-state free precession imaging in the ex vivo macaque brain on a 10.5T human MRI scanner.bioRxiv : the preprint server for biology · 2025Article
- Clinically feasible liver tumour cell size measurement through histology-informed in vivo diffusion MRI.Communications medicine · 2025Article
- Micron-resolution fiber mapping in histology independent of sample preparation.Nature communications · 2025Article
- Micron-resolution fiber mapping in histology independent of sample preparation.bioRxiv : the preprint server for biology · 2025Article
- Cross-species neuroanatomy in primates using tractography.Brain structure & function · 2025Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Mapping how neurons are structurally wired into whole-brain networks can be challenging, particularly in larger brains where 3D microscopy is not available. Multi-modal datasets combining MRI and microscopy provide a solution, where high resolution but 2D microscopy can be complemented by whole-brain but lowresolution MRI. However, there lacks unified approaches to integrate and jointly analyse these multi-modal data in an insightful way. To address this gap, we introduce a data-fusion method for hybrid MRI-microscopy fibre orientation and connectome reconstruction. Specifically, we complement precise "in-plane" orientations from microscopy with "through-plane" information from MRI to construct 3D hybrid fibre orientations at resolutions far exceeding that of MRI whilst preserving microscopy's myelin specificity, resulting in superior fibre tracking. Our method is openly available, can be deployed on standard 2D microscopy, including different microscopy contrasts, and is species agnostic, facilitating neuroanatomical investigation in both animal models and human brains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.