ArticleThe Plant cell2025
The kinase CPK5 phosphorylates MICRORCHIDIA1 to promote broad-spectrum disease resistance.
Article in The Plant cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- When fungi knock, nitrilases unlock the auxin arsenal.The Plant cell · 2026Article
- Calcium-Dependent Protein Kinases in Plants: Structure, Signaling, and Multifaceted Regulatory Roles in Development and Stress Adaptation.International journal of molecular sciences · 2026Review
- Role of AtCPK5 and AtCPK6 in the regulation of the plant immune response triggered by rhamnolipids in Arabidopsis.PloS one · 2026Article
- The complex immune puzzle: A deeper dive into the MORC1-mediated broad-spectrum defense signaling pathway.The Plant cell · 2025Article
- Calcium-dependent protein kinases in plant immunity: from calcium signaling to network integration.Frontiers in plant science · 2025Review
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Authors and funding
15 authors.
Funding
Abstract
In Arabidopsis (Arabidopsis thaliana), MICRORCHIDIA 1 (MORC1), a member of the MORC family of evolutionarily conserved GHKL-type ATPases, plays important roles in multiple layers of plant immunity. However, the molecular mechanism by which MORC1 regulates plant immunity remains obscure. Here, we report that the pathogen-responsive kinase CALCIUM-DEPENDENT PROTEIN KINASE 5 (CPK5) directly interacts with and phosphorylates MORC1, thereby promoting its stability and nuclear translocation. In the nucleus, MORC1 associates with the NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1)-TGACG-BINDING FACTOR (TGA) transcriptional complex to upregulate defense-responsive genes and promote plant resistance against several pathogens, such as the bacterial pathogen Pseudomonas syringae pv. tomato DC3000 and fungal pathogen Botrytis cinerea. Therefore, this study uncovers a MORC1-mediated immune signaling pathway, in which the CPK5-MORC1-NPR1-TGA module transduces Ca2+ signals, leading to the upregulation of defense genes involved in plant immunity.
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