Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
16 authors.
Samuel UsherDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.ORCID 0000-0002-2487-6547
Estelle ToulméInstitut für Neurophysiologie, Charité-Universitätsmedizin, 10117 Berlin, Germany.ORCID 0000-0001-8734-3484
Roberta FloreaDepartment of Biology, Institute of Molecular Systems Biology, ETH Zurich, Otto-Stern-Weg 3, Zürich 8093, Switzerland.ORCID 0009-0002-2716-1560
Stanislau YatskevichDepartment of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.ORCID 0000-0003-2999-6561
Christine C JaoDepartment of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.ORCID 0009-0003-2597-8937
Luuk R H DijkhofDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.ORCID 0009-0007-6928-0513
Janne M ColdingDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.
Prajakta JoshiDepartment of Biomolecular Resources, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Inna ZilberleybDepartment of Biomolecular Resources, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Thorsten TrimbuchInstitut für Neurophysiologie, Charité-Universitätsmedizin, 10117 Berlin, Germany.ORCID 0000-0001-7512-8955
Bettina BrokowskiInstitut für Neurophysiologie, Charité-Universitätsmedizin, 10117 Berlin, Germany.
Alexander S HauserDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.ORCID 0000-0003-1098-6419
Alexander LeitnerDepartment of Biology, Institute of Molecular Systems Biology, ETH Zurich, Otto-Stern-Weg 3, Zürich 8093, Switzerland.ORCID 0000-0003-4126-0725
Christian RosenmundInstitut für Neurophysiologie, Charité-Universitätsmedizin, 10117 Berlin, Germany.ORCID 0000-0002-3905-2444
Marc KschonsakDepartment of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.ORCID 0000-0002-4392-1614
Stephan A PlessDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.ORCID 0000-0001-6654-114X
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
NALCN (sodium leak channel, nonselective) is vital for regulating electrical activity in neurons and other excitable cells, and mutations in the channel or its auxiliary proteins lead to severe neurodevelopmental disorders. Here, we show that the neuronal SNARE (soluble
Indexed as
Ion ChannelsNeuronsSNARE ProteinsSodium ChannelsSynaptosomal-Associated Protein 25AnimalsHEK293 CellsHumansMembrane ProteinsMiceQa-SNARE ProteinsRatsSynaptic TransmissionIon ChannelsMembrane ProteinsNALCN protein, humanQa-SNARE ProteinsSNARE ProteinsSodium ChannelsSynaptosomal-Associated Protein 25
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The sodium leak channel NALCN is regulated by neuronal SNARE complex proteins. · full record | OpenQuestion