Evidence map›Paper›PMID 40085529›Full record

ReviewCancer reports (Hoboken, N.J.)2025

Research Progress on the Role of Zinc Finger Protein in Colorectal Cancer.

Tang Yu, Jiumei Zhao, Ziwei Li, Chenglong Pan, Jialing Liu, Kepu Zheng, Xiaohao Wang, Yan Zhang

Abstract readReview
In one paragraph

Review in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tang YuThe Third Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, China.ORCID 0000-0001-8152-1235
Jiumei ZhaoChongqing Nanchuan District People's Hospital, Chongqing Medical University, Chongqing, China.
Ziwei LiDepartment of Gynecology and Obstetrics, Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Chenglong PanThe Third Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, China.
Jialing LiuThe Third Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, China.
Kepu ZhengThe Third Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, China.
Xiaohao WangDepartment of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Yan ZhangDepartment of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Funding

Natural Science Foundation of Chongqing CSTB2023NSCQMSX0715Program for Youth Innovation in Future Medicine, Chongqing Medical University W0082Scientific Research project of Education Department of Yunnan Province 2023Y0787
6 · The paper itself

Abstract

backgroundColorectal cancer is one of the most prevalent malignancies worldwide, with a tendency of increasing incidence in developed countries, which poses a significant threat to the patients' physical and mental health. RECENT

findingsThe process of gene transcription affects the important physiological functions of cells, so the normal expression of transcription factors is an important prerequisite for maintaining cellular homeostasis. Changes in the level of zinc finger proteins, the most prevalent transcription factor, may play an important trigger for the development of colorectal cancer. Different zinc finger proteins play different roles in terms of promoting or inhibiting cancer development.

conclusionThis paper briefly reviews the classification, functional characteristics, and expression changes of zinc finger proteins in colorectal cancer, it focuses on how they regulate gene transcription, influence on common signaling pathways, and their potential for translational studies and clinical applications. The objective is to stimulate new ideas for their study of colorectal cancer while also providing foundational information to guide drug development and treatment strategies for colorectal cancer patients in clinical settings.

Indexed as

Colorectal NeoplasmsTranscription FactorsZinc FingersGene Expression Regulation, NeoplasticHumansSignal TransductionTranscription Factorscolorectal cancermechanism of actionsignaling pathwaytreatmentzinc finger protein

Identifiers

PMID40085529
PMCPMC11908617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.