Evidence map›Paper›PMID 40085488›Full record

ArticleAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2025

Association of Frailty With Clinical Outcomes in Patients Receiving Primary Prevention Implantable Cardioverter Defibrillators: A Prospective Cohort Study.

Dmitry Neymark, Christopher Lee, William F McIntyre, Maria Higgins, James W Tam, Colette Seifer

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Article in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Dmitry NeymarkSection of Cardiology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.ORCID 0000-0001-9569-2123
Christopher LeeDivision of Cardiology, University of Calgary, Calgary, Alberta, Canada.
William F McIntyreSection of Cardiology, Department of Internal Medicine, McMaster University, Hamilton, Ontario, Canada.
Maria HigginsSection of Cardiology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
James W TamSection of Cardiology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Colette SeiferSection of Cardiology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFrailty predisposes individuals to morbidity and mortality. Increasing numbers of elderly and comorbid individuals are undergoing primary prevention implantable cardioverter defibrillator (ICD) device placement. Little is known about the association of frailty with post-device implantation outcomes.

methodsWe conducted a single-center, prospective cohort study of 71 patients who underwent primary prevention ICD insertion and who had their baseline frailty status assessed using the Fried index. Participants were followed for a median period of 7.8 years.

resultsThe mean age (± SD) was 70.6 ± 4.5 years. 12 (17%) patients met the criteria for frailty. 23 (33%) patients received cardiac resynchronization therapy. Frailty was associated with a significantly higher incidence of mortality (HR [95% CI]; 3.9 [1.2-12.1]), ED visits (2.7 [1.1-6.7]), and hospitalizations (2.8 [1.1-7.6]). Within the non-frail cohort, there was no association between Fried frailty scores and adverse outcomes. None of the frail patients received appropriate shock therapy.

conclusionAmong primary prevention ICD recipients, frailty is associated with worse mortality and morbidity. Clinicians should consider frailty when discussing risks and benefits with this patient population.

Indexed as

Death, Sudden, CardiacDefibrillators, ImplantableFrailtyPrimary PreventionAgedCohort StudiesElectrocardiographyFemaleFrail ElderlyHumansMaleMiddle AgedProspective StudiesTreatment Outcomecardiac resynchronization therapycardiovascular diseaseCRTCVDfrailty assessmentICDimplantable cardioverter defibrillatorprimary preventionSCDsudden cardiac death

Identifiers

PMID40085488
PMCPMC11908439

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.