ArticleSexually transmitted diseases2025
Patterns of Congenital Syphilis in a Large Public Hospital: Maternal Risk Factors and Infant Outcomes.
Article in Sexually transmitted diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Clinical characteristics and factors contributing to transmission of congenital syphilis in England, 2015-24: a national surveillance study.The Lancet regional health. Europe · 2026Article
- An exploratory intersectional analysis of lifetime syphilis prevalence among people who inject drugs in Montreal, Canada.Sexually transmitted diseases · 2026Article
- The Congenital Syphilis Surge: Clinician Lessons to Turn the Rising Tide.Advances in pediatrics · 2026Review
- Identifying missed prevention opportunities: maternal and congenital syphilis in hospital records and birth certificates in California from 2011 to 2021.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Bridging Gaps in Congenital Syphilis Care: A Quality Improvement Initiative for Comprehensive Management at a Large Public Hospital in Los Angeles, California, USA.Sexually transmitted diseases · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundCongenital syphilis (CS) in the United States increased 10-fold in the last decade. At a large public hospital in Los Angeles, the numbers of infants born to mothers with untreated syphilis during pregnancy have continued to rise.
methodsWe compiled a retrospective case series from all infant rapid plasma reagin test results from 2022 to 2023 summarizing CS diagnosis and relevant diagnostic criteria. χ2 and Fisher exact tests were used to examine associations between maternal risk factors and CS diagnosis.
resultsMaternal syphilis complicated 97 of 2367 live births (4.1%) at our institution. Approximately 36% (n = 35) of infants born to mothers with a history of syphilis (n = 94) were born to a mother with inadequately treated syphilis or concern for reinfection. Infants with exposure to maternal syphilis were mostly asymptomatic at birth but had a high frequency of abnormalities in laboratory and radiographic evaluation. Compared with infants with less likely or unlikely CS, mothers of infants with highly probable or possible CS were more likely to have methamphetamine use during pregnancy (41% vs. 69%, P = 0.02), cocaine use during pregnancy (2% vs. 14%, P = 0.03), opiate use during pregnancy (7% vs. 37%, P = <0.001), and no prenatal care (7% vs. 40%, P ≤ 0.001).
conclusionsThis case series identified maternal substance use and no prenatal care as risk factors for highly probable or possible CS, underscoring the vulnerability of this population and informing future work in prevention of this disease.
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