ArticleDiscover oncology2025
Efficacy and safety of immunotherapy plus chemotherapy in advanced or metastatic pulmonary large-cell neuroendocrine carcinoma.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Phase II study of 1st-line durvalumab and platinum-etoposide in advanced large-cell neuroendocrine lung carcinoma (aLCNEC).Cancer immunology, immunotherapy : CII · 2026Trial
- Article
- Construction and validation of a prognostic prediction model for critically ill lung cancer patients based on respiratory functional reserve and systemic inflammatory characteristics.American journal of cancer research · 2026Article
- Examining the effectiveness of follow-up chemotherapy in large cell neuroendocrine carcinoma: special emphasis on stage T1-2N0M0 according to 9Translational cancer research · 2025Article
- A favorable antitumor efficacy of sotorasib in a patient withInternational cancer conference journal · 2025Article
- Pure Large Cell Neuroendocrine Carcinoma Originating from the Endometrium: A Case Report and Review of Literature.Journal of mid-life healthArticle
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7 authors.
Funding
Abstract
backgroundPatients with advanced pulmonary large-cell neuroendocrine carcinoma (LCNEC) have a progressive clinical course and poor prognosis, and effective treatment options remain limited. This study assessed the efficacy and safety of immunotherapy plus chemotherapy for advanced LCNEC.
methodsWe retrospectively collected medical records of patients with advanced LCNEC who attended Shandong Cancer Hospital from January 2018 to December 2022. Patients were divided into two groups based on their previous treatment regimen: immunotherapy plus chemotherapy and chemotherapy alone. Kaplan-Meier survival curves and Cox regression models were used to evaluate the clinical efficacy of different treatment regimens.
resultsThe median follow-up was 29.33 months (95% confidence interval [CI]: 24.04-not reached). The median overall survival (OS) was 15.01 months (95% CI: 11.99-26.31) and 7.19 months (95% CI: 5.15-10.57) in the immunotherapy plus chemotherapy and chemotherapy groups, respectively (P = 0.001). Following propensity score matching, the median OS was 17.41 months (95% CI: 11.99-29.20) and 5.88 months (95% CI: 4.50-11.53) in the immunotherapy plus chemotherapy and chemotherapy groups, respectively. The median progression-free survival was 6.70 months (95% CI: 5.48-13.27) and 3.12 months (95% CI: 2.52-4.20) in the immunotherapy plus chemotherapy and chemotherapy groups, respectively. We also found that increasing age may contribute to poorer prognosis in patients with advanced LCNEC (P < 0.05).
conclusionsImmunotherapy plus chemotherapy significantly improved OS compared with chemotherapy in LCNEC, with a tolerable safety profile without life-threatening adverse events. Immunotherapy plus chemotherapy may be an effective treatment option for patients with advanced LCNEC.
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