Evidence map›Paper›PMID 40085386›Full record

ArticleMaternal and child health journal2025

Prevalence and Clinical Features of Pulmonary Embolism in Pregnancy and Puerperium in the Post-COVID-19 Era.

Thai Lun Tan, Noor Emillia Binti Illa, Siew Ying Ting, Shoen Chuen Chiew, De Yee Gan, Zhong Wei Ong, Vijayan

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Article in Maternal and child health journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Thai Lun TanDepartment of Internal Medicine, Hospital Tengku Ampuan Rahimah, Ministry of Health, Jalan Langat, Klang, Selangor, 41200, Malaysia. tanthailun@gmail.com.ORCID http://orcid.org/0000-0002-7337-0550
Noor Emillia Binti IllaDepartment of Radiology, Hospital Tengku Ampuan Rahimah, Ministry of Health, Jalan Langat, Klang, Selangor, 41200, Malaysia.
Siew Ying TingClinical Research Centre, Hospital Seri Manjung, Ministry of Health, Seri Manjung, Perak, 32040, Malaysia.
Shoen Chuen ChiewClinical Research Centre, Hospital Seri Manjung, Ministry of Health, Seri Manjung, Perak, 32040, Malaysia.ORCID http://orcid.org/0000-0002-5302-7149
De Yee GanDepartment of Internal Medicine, Hospital Tengku Ampuan Rahimah, Ministry of Health, Jalan Langat, Klang, Selangor, 41200, Malaysia.
Zhong Wei OngDepartment of Obstetrics and Gynaecology, Hospital Tengku Ampuan Rahimah, Ministry of Health, Jalan Langat, Klang, Selangor, 41200, Malaysia.
VijayanDepartment of Internal Medicine, Hospital Tengku Ampuan Rahimah, Ministry of Health, Jalan Langat, Klang, Selangor, 41200, Malaysia.

Funding

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6 · The paper itself

Abstract

objectiveInterest in pulmonary embolism (PE) has undergone a renaissance since the emergence of COVID-19 pandemic, but PE researches among pregnant mothers in this post-COVID-19 era remains scarce. This study was conducted to (a) determine PE prevalence rate among pregnant and post-partum women with suspected PE after the COVID 19 pandemic, (b) compare the clinical characteristics, laboratory findings and CT features between the PE and non-PE cohorts, and (c) validate the Pregnancy-Adapted Geneva (PAG) score in our population.

methodsThis retrospective cross-sectional study involved the review of all maternal cases with suspected PE who underwent diagnostic CTPA in year 2022.

resultsA total of 120 patients represented by 90 pregnant patients and 30 post-partum patients were included in the analysis. The prevalence rate of PE was 22.5% (27/120) and gestational diabetes mellitus prevalence rate was significantly higher (48.1% vs. 26.9%; p = 0.037) in PE cohort. Besides, the proportion of patients with moderately and extremely raised peak D-dimer levels were significantly higher among the PE cohort. In patients with PE, the position of the most proximal clot was identified as subsegmental (n = 6, 22.2%) and segmental (n = 21; 77.8%). The predicted PE risk based on PAG score demonstrated poor calibration with the observed PE risk across all three groups, namely low-risk group (2.3% vs. 15.4%), intermediate-risk group (11.6% vs. 26.3%) and high-risk groups (61.5% vs. 0.0%).

conclusionOverall, PE among pregnant and post-partum populations remain a convoluted disease without distinctive clinical features. There is a need for a prospectively validated PE risk scores to guide its clinical diagnostic pathway.

Indexed as

COVID-19Pulmonary EmbolismAdultCross-Sectional StudiesDiabetes, GestationalFemaleFibrin Fibrinogen Degradation ProductsHumansPostpartum PeriodPregnancyPrevalenceRetrospective StudiesRisk FactorsSARS-CoV-2Fibrin Fibrinogen Degradation Productsfibrin fragment DComputed tomography pulmonary angiogramPost-COVID-19 eraPregnancyPuerperiumPulmonary embolism

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